tetano
Editor, Senior Moderator
Biomed Rep
. 2023 Oct 16;19(6):95.
doi: 10.3892/br.2023.1677. eCollection 2023 Dec. IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals
Nicolle Rakanidis Machado[SUP] 1 [/SUP], Beatriz Oliveira Fagundes[SUP] 1 [/SUP], Iara Grigoletto Fernandes[SUP] 1 [/SUP], Daniela Terra De Apoena Reche[SUP] 2 [/SUP], Maria Notomi Sato[SUP] 1 [/SUP], Jefferson Russo Victor[SUP] 1 2 3 [/SUP]
Affiliations
Lower levels of peripheral mucosal-associated invariant T (MAIT) cells have been observed in the peripheral blood of patients with severe coronavirus disease 2019 (COVID-19). Following on from previous research into the effect of the IgG repertoire on human lymphocytes, the present study aimed to evaluate if immunoglobulin G (IgG) antibodies obtained from patients with mild or severe COVID-19 contribute to these effects on MAIT cells. Culture experiments were performed using healthy human peripheral blood mononuclear cells (PBMCs) and different repertoires of IgG obtained from patients with COVID-19 as a mild or severe disease and compared with mock, healthy control or therapeutic IgG conditions. The results indicate that the IgG repertoire induced during the development of mild and severe COVID-19 has, per se, the in vitro potential to reduce the frequency of MAIT cells and the production of IFN-γ by the MAIT cell population in PBMCs from healthy individuals. In conclusion, the results of the present study indicate that IgG in patients with severe COVID-19 may participate in the reduction of peripheral MAIT cell frequency and hinder the antiviral activity of these cells.
Keywords: COVID-19; IFN-γ; IL-17; IgG; mucosal-associated invariant T cells.
. 2023 Oct 16;19(6):95.
doi: 10.3892/br.2023.1677. eCollection 2023 Dec. IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals
Nicolle Rakanidis Machado[SUP] 1 [/SUP], Beatriz Oliveira Fagundes[SUP] 1 [/SUP], Iara Grigoletto Fernandes[SUP] 1 [/SUP], Daniela Terra De Apoena Reche[SUP] 2 [/SUP], Maria Notomi Sato[SUP] 1 [/SUP], Jefferson Russo Victor[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37901873
- PMCID: PMC10603374
- DOI: 10.3892/br.2023.1677
Lower levels of peripheral mucosal-associated invariant T (MAIT) cells have been observed in the peripheral blood of patients with severe coronavirus disease 2019 (COVID-19). Following on from previous research into the effect of the IgG repertoire on human lymphocytes, the present study aimed to evaluate if immunoglobulin G (IgG) antibodies obtained from patients with mild or severe COVID-19 contribute to these effects on MAIT cells. Culture experiments were performed using healthy human peripheral blood mononuclear cells (PBMCs) and different repertoires of IgG obtained from patients with COVID-19 as a mild or severe disease and compared with mock, healthy control or therapeutic IgG conditions. The results indicate that the IgG repertoire induced during the development of mild and severe COVID-19 has, per se, the in vitro potential to reduce the frequency of MAIT cells and the production of IFN-γ by the MAIT cell population in PBMCs from healthy individuals. In conclusion, the results of the present study indicate that IgG in patients with severe COVID-19 may participate in the reduction of peripheral MAIT cell frequency and hinder the antiviral activity of these cells.
Keywords: COVID-19; IFN-γ; IL-17; IgG; mucosal-associated invariant T cells.