tetano
Editor, Senior Moderator
Biomed Pharmacother
. 2023 Oct 14:168:115637.
doi: 10.1016/j.biopha.2023.115637. Online ahead of print. The potential role of ferroptosis in COVID-19-related cardiovascular injury
Lei Yang[SUP] 1 [/SUP], Yunyi Wu[SUP] 2 [/SUP], Weidong Jin[SUP] 2 [/SUP], Nan Mo[SUP] 3 [/SUP], Gaoqi Ye[SUP] 2 [/SUP], Zixin Su[SUP] 2 [/SUP], Lusheng Tang[SUP] 2 [/SUP], Ying Wang[SUP] 4 [/SUP], Yanchun Li[SUP] 5 [/SUP], Jing Du[SUP] 6 [/SUP]
Affiliations
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a global health threat in 2019. An important feature of the disease is that multiorgan symptoms of SARS-CoV-2 infection persist after recovery. Evidence indicates that people who recovered from COVID-19, even those under the age of 65 years without cardiovascular risk factors such as smoking, obesity, hypertension, and diabetes, had a significantly increased risk of cardiovascular disease for up to one year after diagnosis. Therefore, it is important to closely monitor individuals who have recovered from COVID-19 for potential cardiovascular damage that may manifest at a later stage. Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by the production of reactive oxygen species (ROS) and increased lipid peroxide levels. Several studies have demonstrated that ferroptosis plays an important role in cancer, ischemia/reperfusion injury (I/RI), and other cardiovascular diseases. Altered iron metabolism, upregulation of reactive oxygen species, and glutathione peroxidase 4 inactivation are striking features of COVID-19-related cardiovascular injury. SARS-CoV-2 can cause cardiovascular ferroptosis, leading to cardiovascular damage. Understanding the mechanism of ferroptosis in COVID-19-related cardiovascular injuries will contribute to the development of treatment regimens for preventing or reducing COVID-19-related cardiovascular complications. In this article, we go over the pathophysiological underpinnings of SARS-CoV-2-induced acute and chronic cardiovascular injury, the function of ferroptosis, and prospective treatment approaches.
Keywords: COVID-19; Cardiovascular injury; Ferroptosis; Iron; Long-COVID; SARS-CoV-2.
. 2023 Oct 14:168:115637.
doi: 10.1016/j.biopha.2023.115637. Online ahead of print. The potential role of ferroptosis in COVID-19-related cardiovascular injury
Lei Yang[SUP] 1 [/SUP], Yunyi Wu[SUP] 2 [/SUP], Weidong Jin[SUP] 2 [/SUP], Nan Mo[SUP] 3 [/SUP], Gaoqi Ye[SUP] 2 [/SUP], Zixin Su[SUP] 2 [/SUP], Lusheng Tang[SUP] 2 [/SUP], Ying Wang[SUP] 4 [/SUP], Yanchun Li[SUP] 5 [/SUP], Jing Du[SUP] 6 [/SUP]
Affiliations
- PMID: 37844358
- DOI: 10.1016/j.biopha.2023.115637
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a global health threat in 2019. An important feature of the disease is that multiorgan symptoms of SARS-CoV-2 infection persist after recovery. Evidence indicates that people who recovered from COVID-19, even those under the age of 65 years without cardiovascular risk factors such as smoking, obesity, hypertension, and diabetes, had a significantly increased risk of cardiovascular disease for up to one year after diagnosis. Therefore, it is important to closely monitor individuals who have recovered from COVID-19 for potential cardiovascular damage that may manifest at a later stage. Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by the production of reactive oxygen species (ROS) and increased lipid peroxide levels. Several studies have demonstrated that ferroptosis plays an important role in cancer, ischemia/reperfusion injury (I/RI), and other cardiovascular diseases. Altered iron metabolism, upregulation of reactive oxygen species, and glutathione peroxidase 4 inactivation are striking features of COVID-19-related cardiovascular injury. SARS-CoV-2 can cause cardiovascular ferroptosis, leading to cardiovascular damage. Understanding the mechanism of ferroptosis in COVID-19-related cardiovascular injuries will contribute to the development of treatment regimens for preventing or reducing COVID-19-related cardiovascular complications. In this article, we go over the pathophysiological underpinnings of SARS-CoV-2-induced acute and chronic cardiovascular injury, the function of ferroptosis, and prospective treatment approaches.
Keywords: COVID-19; Cardiovascular injury; Ferroptosis; Iron; Long-COVID; SARS-CoV-2.