tetano
Editor, Senior Moderator
Biomed Pharmacother
. 2021 Apr 23;139:111599.
doi: 10.1016/j.biopha.2021.111599. Online ahead of print.
Novel and emerging mutations of SARS-CoV-2: Biomedical implications
Elmira Mohammadi[SUP] 1 [/SUP], Fatemeh Shafiee[SUP] 2 [/SUP], Kiana Shahzamani[SUP] 3 [/SUP], Mohammad Mehdi Ranjbar[SUP] 4 [/SUP], Abbas Alibakhshi[SUP] 5 [/SUP], Shahrzad Ahangarzadeh[SUP] 6 [/SUP], Leila Beikmohammadi[SUP] 7 [/SUP], Laleh Shariati[SUP] 8 [/SUP], Soodeh Hooshmandi[SUP] 9 [/SUP], Behrooz Ataei[SUP] 10 [/SUP], Shaghayegh Haghjooy Javanmard[SUP] 11 [/SUP]
Affiliations
Abstract
Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.
Keywords: COVID-19; Genetic variation; Mutation; SARS-CoV-2; Spike protein.
. 2021 Apr 23;139:111599.
doi: 10.1016/j.biopha.2021.111599. Online ahead of print.
Novel and emerging mutations of SARS-CoV-2: Biomedical implications
Elmira Mohammadi[SUP] 1 [/SUP], Fatemeh Shafiee[SUP] 2 [/SUP], Kiana Shahzamani[SUP] 3 [/SUP], Mohammad Mehdi Ranjbar[SUP] 4 [/SUP], Abbas Alibakhshi[SUP] 5 [/SUP], Shahrzad Ahangarzadeh[SUP] 6 [/SUP], Leila Beikmohammadi[SUP] 7 [/SUP], Laleh Shariati[SUP] 8 [/SUP], Soodeh Hooshmandi[SUP] 9 [/SUP], Behrooz Ataei[SUP] 10 [/SUP], Shaghayegh Haghjooy Javanmard[SUP] 11 [/SUP]
Affiliations
- PMID: 33915502
- DOI: 10.1016/j.biopha.2021.111599
Abstract
Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.
Keywords: COVID-19; Genetic variation; Mutation; SARS-CoV-2; Spike protein.