tetano
Editor, Senior Moderator
Biomed Microdevices
. 2025 Oct 27;27(4):48.
doi: 10.1007/s10544-025-00779-6. Ultra-low detection of SARS-CoV-2 Virus Like Particles (VLPs) with functionalized gold plasmonic nanoresonator array
Dipanjan Nandi[SUP] 1 [/SUP], Jiaxin Fan[SUP] 1 [/SUP], Seongdae Kang[SUP] 2 [/SUP], Manisha Gupta[SUP] 3 [/SUP]
Affiliations
Localized surface plasmon resonance (LSPR) sensors have good potential for label-free non-invasive detection of biomolecules, healthcare diagnosis, disease monitoring, gas sensing, and food safety. For detection of low concentration small-sized bioanalytes (e.g., viruses, proteins, etc) the plasmonic field needs to be localized on a larger device surface area. Our study focuses on the optimization and fabrication of leaky Au nanoresonators based sensing platform for SARS-CoV-2 detection with uniform sensitivity over a 100 μm × 100 μm active sensing area. The Au nanoresonator array was optimized to detect 100 nm sized bioanalytes as it matches the size of SARS-CoV-2. The performance of the optimized design was tested with 100 nm sized polystyrene beads which demonstrated a sensitivity of 17.05 ± 3.25 nm/decade. The Au nanoresonators were functionalized with anti-SARS-CoV-2 antibody to detect SARS-CoV-2. Our experimental results demonstrate the best detection sensitivity of 1.32 ± 0.08 nm/decade and limit of detection of 1 VLP μL[Formula: see text].
Keywords: Au nanoresonators; FDTD; LSPR sensors; Nanophotonics; SARS-CoV-2 detection.
. 2025 Oct 27;27(4):48.
doi: 10.1007/s10544-025-00779-6. Ultra-low detection of SARS-CoV-2 Virus Like Particles (VLPs) with functionalized gold plasmonic nanoresonator array
Dipanjan Nandi[SUP] 1 [/SUP], Jiaxin Fan[SUP] 1 [/SUP], Seongdae Kang[SUP] 2 [/SUP], Manisha Gupta[SUP] 3 [/SUP]
Affiliations
- PMID: 41143945
- DOI: 10.1007/s10544-025-00779-6
Localized surface plasmon resonance (LSPR) sensors have good potential for label-free non-invasive detection of biomolecules, healthcare diagnosis, disease monitoring, gas sensing, and food safety. For detection of low concentration small-sized bioanalytes (e.g., viruses, proteins, etc) the plasmonic field needs to be localized on a larger device surface area. Our study focuses on the optimization and fabrication of leaky Au nanoresonators based sensing platform for SARS-CoV-2 detection with uniform sensitivity over a 100 μm × 100 μm active sensing area. The Au nanoresonator array was optimized to detect 100 nm sized bioanalytes as it matches the size of SARS-CoV-2. The performance of the optimized design was tested with 100 nm sized polystyrene beads which demonstrated a sensitivity of 17.05 ± 3.25 nm/decade. The Au nanoresonators were functionalized with anti-SARS-CoV-2 antibody to detect SARS-CoV-2. Our experimental results demonstrate the best detection sensitivity of 1.32 ± 0.08 nm/decade and limit of detection of 1 VLP μL[Formula: see text].
Keywords: Au nanoresonators; FDTD; LSPR sensors; Nanophotonics; SARS-CoV-2 detection.