tetano
Editor, Senior Moderator
Biomed J
. 2022 Aug 26;S2319-4170(22)00134-2.
doi: 10.1016/j.bj.2022.08.005. Online ahead of print.
Hypocalcemia: a key biomarker in hospitalized COVID-19 patients
M J Ruiz-Álvarez[SUP] 1 [/SUP], Emanuela Stampone[SUP] 2 [/SUP], Yaiza Fernández Verduras[SUP] 1 [/SUP], Giovanni Gallo[SUP] 2 [/SUP], Marta Barrionuevo González[SUP] 1 [/SUP], Belén Beteré Cubillo[SUP] 1 [/SUP], Debora Bencivenga[SUP] 2 [/SUP], Fulvio Della Ragione[SUP] 2 [/SUP], Adriana Borriello[SUP] 3 [/SUP]
Affiliations
Abstract
Background: At the end of 2019 a new respiratory syndrome emerged in China named Coronavirus disease 2019 (COVID-19). Considering the severity of the disease in adult subjects with one or more chronic pathologies, it was mandatory to find simple and effective biomarkers for negative prognosis of the disease easily available at the admission to the hospital.
Material and methods: To identify possible parameters showing association with the outcome in COVID-19 patients with previous chronic diseases, blood biochemical profiles of 511 patients, enrolled from March to June 2020, were retrospectively evaluated. The pathologies taken into consideration were diabetes, arterial hypertension, chronic kidney disease, cardiovascular diseases, chronic obstructive pulmonary disease, obesity, and cancer. All the data were collected upon admission to the emergency room (ER) during the indicated period.
Results and discussion: In accord with previous studies, we observed that serum and ionized calcium were prevalently altered in our cohort. We determined that hypocalcemia was a major parameter associated with mechanical ventilation and poor prognosis, correlating also with the presence of comorbidities such as cardiovascular diseases, chronic kidney disease, and cancer. In addition, we found a positive correlation between hypocalcemia and clinical complications during hospitalizations, strengthening the relevance of calcium concentration as a useful prognostic biomarker in COVID-19 patients.
Keywords: CKD; COVID-19; CVD; SARS-CoV2; biochemical biomarkers; calcium; hypocalcemia.
. 2022 Aug 26;S2319-4170(22)00134-2.
doi: 10.1016/j.bj.2022.08.005. Online ahead of print.
Hypocalcemia: a key biomarker in hospitalized COVID-19 patients
M J Ruiz-Álvarez[SUP] 1 [/SUP], Emanuela Stampone[SUP] 2 [/SUP], Yaiza Fernández Verduras[SUP] 1 [/SUP], Giovanni Gallo[SUP] 2 [/SUP], Marta Barrionuevo González[SUP] 1 [/SUP], Belén Beteré Cubillo[SUP] 1 [/SUP], Debora Bencivenga[SUP] 2 [/SUP], Fulvio Della Ragione[SUP] 2 [/SUP], Adriana Borriello[SUP] 3 [/SUP]
Affiliations
- PMID: 36038109
- DOI: 10.1016/j.bj.2022.08.005
Abstract
Background: At the end of 2019 a new respiratory syndrome emerged in China named Coronavirus disease 2019 (COVID-19). Considering the severity of the disease in adult subjects with one or more chronic pathologies, it was mandatory to find simple and effective biomarkers for negative prognosis of the disease easily available at the admission to the hospital.
Material and methods: To identify possible parameters showing association with the outcome in COVID-19 patients with previous chronic diseases, blood biochemical profiles of 511 patients, enrolled from March to June 2020, were retrospectively evaluated. The pathologies taken into consideration were diabetes, arterial hypertension, chronic kidney disease, cardiovascular diseases, chronic obstructive pulmonary disease, obesity, and cancer. All the data were collected upon admission to the emergency room (ER) during the indicated period.
Results and discussion: In accord with previous studies, we observed that serum and ionized calcium were prevalently altered in our cohort. We determined that hypocalcemia was a major parameter associated with mechanical ventilation and poor prognosis, correlating also with the presence of comorbidities such as cardiovascular diseases, chronic kidney disease, and cancer. In addition, we found a positive correlation between hypocalcemia and clinical complications during hospitalizations, strengthening the relevance of calcium concentration as a useful prognostic biomarker in COVID-19 patients.
Keywords: CKD; COVID-19; CVD; SARS-CoV2; biochemical biomarkers; calcium; hypocalcemia.