tetano
Editor, Senior Moderator
Biomarkers
. 2020 Dec 7;1-18.
doi: 10.1080/1354750X.2020.1861098. Online ahead of print.
Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia
Peng Cao[SUP] 1 2 [/SUP], Yuanjue Wu[SUP] 3 [/SUP], Sanlan Wu[SUP] 1 2 [/SUP], Tingting Wu[SUP] 1 2 [/SUP], Qilin Zhang[SUP] 1 2 [/SUP], Rui Zhang[SUP] 1 2 [/SUP], Zhao Wang[SUP] 4 [/SUP], Yu Zhang[SUP] 1 2 [/SUP]
Affiliations
Abstract
Aim: ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown. Method: we collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed.
Results: patients with elevated ferritin levels had a higher incidence of severity illness (50.0% vs 2.9%) and liver injury (52.3% vs 20.0%) when compared with patients with normal ferritin levels (p < 0.05). Ferritin could effectively identify severity illness (ROC area 0.873) and liver injury (ROC area 0.752). Elevated ferritin group showed longer viral clearance time (median 16 vs 6 days, p < 0.001) and in-hospital length (median 18 vs 10 days, p < 0.001). Conclusions: it suggests that ferritin could act as an easy-to-use tool to identify liver injury and severity illness and predict the prognosis of COVID-19 patients. Intensive surveillance is necessary for patients with abnormal ferritin levels.
Keywords: COVID-19; coronavirus; ferritin; liver injury; risk factor.
. 2020 Dec 7;1-18.
doi: 10.1080/1354750X.2020.1861098. Online ahead of print.
Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia
Peng Cao[SUP] 1 2 [/SUP], Yuanjue Wu[SUP] 3 [/SUP], Sanlan Wu[SUP] 1 2 [/SUP], Tingting Wu[SUP] 1 2 [/SUP], Qilin Zhang[SUP] 1 2 [/SUP], Rui Zhang[SUP] 1 2 [/SUP], Zhao Wang[SUP] 4 [/SUP], Yu Zhang[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33284041
- DOI: 10.1080/1354750X.2020.1861098
Abstract
Aim: ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown. Method: we collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed.
Results: patients with elevated ferritin levels had a higher incidence of severity illness (50.0% vs 2.9%) and liver injury (52.3% vs 20.0%) when compared with patients with normal ferritin levels (p < 0.05). Ferritin could effectively identify severity illness (ROC area 0.873) and liver injury (ROC area 0.752). Elevated ferritin group showed longer viral clearance time (median 16 vs 6 days, p < 0.001) and in-hospital length (median 18 vs 10 days, p < 0.001). Conclusions: it suggests that ferritin could act as an easy-to-use tool to identify liver injury and severity illness and predict the prognosis of COVID-19 patients. Intensive surveillance is necessary for patients with abnormal ferritin levels.
Keywords: COVID-19; coronavirus; ferritin; liver injury; risk factor.