tetano
Editor, Senior Moderator
Biomark Insights
. 2021 Jun 4;16:11772719211021647.
doi: 10.1177/11772719211021647. eCollection 2021.
Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
Katja Tromp[SUP] 1 [/SUP], Philip van der Zee[SUP] 1 [/SUP], Casper Rokx[SUP] 2 [/SUP], Jeroen van Kampen[SUP] 3 [/SUP], Diederik Gommers[SUP] 1 [/SUP], Henrik Endeman[SUP] 1 [/SUP]
Affiliations
Abstract
Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.
Keywords: COVID-19; acute respiratory distress syndrome; coagulation; corticosteroids; inflammation; mechanical ventilation.
. 2021 Jun 4;16:11772719211021647.
doi: 10.1177/11772719211021647. eCollection 2021.
Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
Katja Tromp[SUP] 1 [/SUP], Philip van der Zee[SUP] 1 [/SUP], Casper Rokx[SUP] 2 [/SUP], Jeroen van Kampen[SUP] 3 [/SUP], Diederik Gommers[SUP] 1 [/SUP], Henrik Endeman[SUP] 1 [/SUP]
Affiliations
- PMID: 34158797
- PMCID: PMC8182185
- DOI: 10.1177/11772719211021647
Abstract
Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.
Keywords: COVID-19; acute respiratory distress syndrome; coagulation; corticosteroids; inflammation; mechanical ventilation.