tetano
Editor, Senior Moderator
Bioinformatics. 2020 May 6. pii: btaa285. doi: 10.1093/bioinformatics/btaa285. [Epub ahead of print]
COVID-2019 associated overexpressed Prevotella proteins mediated host-pathogen interactions and their role in coronavirus outbreak.
Khan AA[SUP]1[/SUP], Khan Z[SUP]2[/SUP].
Author information
Abstract
MOTIVATION:
The outbreak of COVID-2019 initiated at Wuhan, China has become a global threat by rapid transmission and severe fatalities. Recent studies have uncovered whole genome sequence of SARS-CoV-2 (causing COVID-2019). In addition, lung metagenomic studies on infected patients revealed overrepresented Prevotella spp. producing certain proteins in abundance. We performed host-pathogen protein-protein interaction analysis between SARS-CoV-2 and overrepresented Prevotella proteins with human proteome. We also performed functional overrepresentation analysis of interacting proteins to understand their role in COVID-2019 severity.
RESULTS:
It was found that over-expressed Prevotella proteins can promote viral infection. As per the results, Prevotella proteins, but not viral proteins are involved in multiple interactions with NF-kB, which is involved in increasing clinical severity of COVID-2019. Prevotella may have role in COVID-2019 outbreak and should be given importance for understanding disease mechanisms and improving treatment outcomes.
SUPPLEMENTARY INFORMATION:
Supplementary data are available at Bioinformatics online.
? The Author(s) (2020). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PMID:32374823DOI:10.1093/bioinformatics/btaa285
COVID-2019 associated overexpressed Prevotella proteins mediated host-pathogen interactions and their role in coronavirus outbreak.
Khan AA[SUP]1[/SUP], Khan Z[SUP]2[/SUP].
Author information
Abstract
MOTIVATION:
The outbreak of COVID-2019 initiated at Wuhan, China has become a global threat by rapid transmission and severe fatalities. Recent studies have uncovered whole genome sequence of SARS-CoV-2 (causing COVID-2019). In addition, lung metagenomic studies on infected patients revealed overrepresented Prevotella spp. producing certain proteins in abundance. We performed host-pathogen protein-protein interaction analysis between SARS-CoV-2 and overrepresented Prevotella proteins with human proteome. We also performed functional overrepresentation analysis of interacting proteins to understand their role in COVID-2019 severity.
RESULTS:
It was found that over-expressed Prevotella proteins can promote viral infection. As per the results, Prevotella proteins, but not viral proteins are involved in multiple interactions with NF-kB, which is involved in increasing clinical severity of COVID-2019. Prevotella may have role in COVID-2019 outbreak and should be given importance for understanding disease mechanisms and improving treatment outcomes.
SUPPLEMENTARY INFORMATION:
Supplementary data are available at Bioinformatics online.
? The Author(s) (2020). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PMID:32374823DOI:10.1093/bioinformatics/btaa285