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Bioeng Transl Med . Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and

tetano

tetano

Editor, Senior Moderator
Bioeng Transl Med


. 2020 Dec 12;e10202.
doi: 10.1002/btm2.10202. Online ahead of print.
Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice


Chaiyaporn Kuwentrai[SUP] 1 [/SUP], Jinming Yu[SUP] 2 [/SUP], Li Rong[SUP] 1 [/SUP], Bao-Zhong Zhang[SUP] 1 3 [/SUP], Ye-Fan Hu[SUP] 1 4 [/SUP], Hua-Rui Gong[SUP] 1 [/SUP], Ying Dou[SUP] 1 [/SUP], Jian Deng[SUP] 1 [/SUP], Jian-Dong Huang[SUP] 1 3 [/SUP], Chenjie Xu[SUP] 2 [/SUP]



Affiliations

Abstract

The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.

Keywords: COVID‐19; SARS‐CoV‐2; intradermal delivery; microneedle; receptor‐binding domain; spike protein.
 
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