tetano
Editor, Senior Moderator
Acta Biochim Pol. 2019 Jul 24;66(3):329-336. doi: 10.18388/abp.2019_2795.
[h=1]Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses.[/h] Mahardika GN[SUP]1[/SUP], Suartha NI[SUP]2[/SUP], Kencana GAY[SUP]1[/SUP], Suardana IBK[SUP]1[/SUP], Mahardika WW[SUP]3[/SUP], Budayanti NS[SUP]4[/SUP].
[h=3]Author information[/h] 1 Virology Laboratory, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia. 2 Animal Hospital, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia. 3 Faculty of Visual Communication Design of Bina Nusantara University, Tanggerang-Banten, Indonesia. 4 Microbiology Department, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia.
[h=3]Abstract[/h] The potential emergence of deadly pandemic influenza viruses is unpredictable and most have emerged with no forewarning. The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a 'template' for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, and isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have full-length PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately.
PMID: 31531422 DOI: 10.18388/abp.2019_2795
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[h=1]Biochemistry and computer generated graph comparison of the structural and nonstructural proteins of spanish-1918 Influenza, pandemic-2009, and bird flu viruses.[/h] Mahardika GN[SUP]1[/SUP], Suartha NI[SUP]2[/SUP], Kencana GAY[SUP]1[/SUP], Suardana IBK[SUP]1[/SUP], Mahardika WW[SUP]3[/SUP], Budayanti NS[SUP]4[/SUP].
[h=3]Author information[/h] 1 Virology Laboratory, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia. 2 Animal Hospital, Faculty of Veterinary Medicine Udayana University, Denpasar, Bali, Indonesia. 3 Faculty of Visual Communication Design of Bina Nusantara University, Tanggerang-Banten, Indonesia. 4 Microbiology Department, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia.
[h=3]Abstract[/h] The potential emergence of deadly pandemic influenza viruses is unpredictable and most have emerged with no forewarning. The distinct epidemiological and pathological patterns of the Spanish (H1N1), pandemic-2009 (H1N1), and avian influenza (H5N1), known as bird flu, viruses may allow us to develop a 'template' for possible emergence of devastating pandemic strains. Here, we provide a detailed molecular dissection of the structural and nonstructural proteins of this triad of viruses. GenBank data for three representative strains were analyzed to determine the polymorphic amino acids, genetic distances, and isoelectric points, hydrophobicity plot, and protein modeling of various proteins. We propose that the most devastating pandemic strains may have full-length PB1-F2 protein with unique residues, highly cleavable HA, and a basic NS1. Any newly emerging strain should be compared with these three strains, so that resources can be directed appropriately.
PMID: 31531422 DOI: 10.18388/abp.2019_2795
Free full text