tetano
Editor, Senior Moderator
Biochem Soc Trans
. 2022 Jan 11;BST20211180.
doi: 10.1042/BST20211180. Online ahead of print.
Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases
Anoop Narayanan[SUP] 1 [/SUP], Shay A Toner[SUP] 1 [/SUP], Joyce Jose[SUP] 1 2 [/SUP]
Affiliations
Abstract
SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, encodes two proteases, 3CLpro and PLpro, two of the main antiviral research targets. Here we provide an overview of the structures and functions of 3CLpro and PLpro and examine strategies of structure-based drug designing and drug repurposing against these proteases. Rational structure-based drug design enables the generation of potent and target-specific antivirals. Drug repurposing offers an attractive prospect with an accelerated turnaround. Thus far, several protease inhibitors have been identified, and some candidates are undergoing trials that may well prove to be effective antivirals against SARS-CoV-2.
Keywords: 3CLpro; COVID-19; PLpro; SARS-CoV-2; antiviral; proteases.
. 2022 Jan 11;BST20211180.
doi: 10.1042/BST20211180. Online ahead of print.
Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases
Anoop Narayanan[SUP] 1 [/SUP], Shay A Toner[SUP] 1 [/SUP], Joyce Jose[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35015073
- DOI: 10.1042/BST20211180
Abstract
SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, encodes two proteases, 3CLpro and PLpro, two of the main antiviral research targets. Here we provide an overview of the structures and functions of 3CLpro and PLpro and examine strategies of structure-based drug designing and drug repurposing against these proteases. Rational structure-based drug design enables the generation of potent and target-specific antivirals. Drug repurposing offers an attractive prospect with an accelerated turnaround. Thus far, several protease inhibitors have been identified, and some candidates are undergoing trials that may well prove to be effective antivirals against SARS-CoV-2.
Keywords: 3CLpro; COVID-19; PLpro; SARS-CoV-2; antiviral; proteases.