tetano
Editor, Senior Moderator
Ann Epidemiol. 2013 Jun;23(6):301-6. doi: 10.1016/j.annepidem.2013.04.005.
Bayesian estimation of the effective reproduction number for pandemic influenza A H1N1 in Guangdong Province, China.
Yang F, Yuan L, Tan X, Huang C, Feng J.
Source
Disease Prevention and Control Institute, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, P. R. China.
Abstract
PURPOSE:
During the course of a pandemic, it is necessary to understand its transmissibility, which is often summarized by the effective reproduction number. Accurate estimation of the effective reproduction number (R) is of vital significance in real-time decision making for coping with pandemic influenza.
METHODS:
We used daily case notification data in Guangdong Province, China, in conjunction with Bayesian inference of two different stochastic susceptible, infectious, recovered (SIR) models to estimate the effective reproduction number. The duration of infectiousness was taken from published literature, and the proportion of imported cases was obtained from individual-level data.
RESULTS:
At the initial epidemic phase, 40% of the first 261 cases were not locally acquired. Explicitly accounting for imported cases and different infectious periods, the possible range of basic reproduction number was preliminarily estimated to be between 1.05 and 1.46. We showed how the daily case reports provided valuable information to estimate the effective reproduction number. We also found the potential delay in reporting had a relatively minor impact on estimating R.
CONCLUSIONS:
Our proposed models and findings provide a relevant contribution towards establishing a basis for monitoring the evolution of emerging infectious diseases in real time and understanding the characteristics of pandemic influenza A H1N1 in Guangdong Province.
Copyright ? 2013 Elsevier Inc. All rights reserved.
PMID:
23683708
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23683708
Bayesian estimation of the effective reproduction number for pandemic influenza A H1N1 in Guangdong Province, China.
Yang F, Yuan L, Tan X, Huang C, Feng J.
Source
Disease Prevention and Control Institute, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, P. R. China.
Abstract
PURPOSE:
During the course of a pandemic, it is necessary to understand its transmissibility, which is often summarized by the effective reproduction number. Accurate estimation of the effective reproduction number (R) is of vital significance in real-time decision making for coping with pandemic influenza.
METHODS:
We used daily case notification data in Guangdong Province, China, in conjunction with Bayesian inference of two different stochastic susceptible, infectious, recovered (SIR) models to estimate the effective reproduction number. The duration of infectiousness was taken from published literature, and the proportion of imported cases was obtained from individual-level data.
RESULTS:
At the initial epidemic phase, 40% of the first 261 cases were not locally acquired. Explicitly accounting for imported cases and different infectious periods, the possible range of basic reproduction number was preliminarily estimated to be between 1.05 and 1.46. We showed how the daily case reports provided valuable information to estimate the effective reproduction number. We also found the potential delay in reporting had a relatively minor impact on estimating R.
CONCLUSIONS:
Our proposed models and findings provide a relevant contribution towards establishing a basis for monitoring the evolution of emerging infectious diseases in real time and understanding the characteristics of pandemic influenza A H1N1 in Guangdong Province.
Copyright ? 2013 Elsevier Inc. All rights reserved.
PMID:
23683708
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23683708