tetano
Editor, Senior Moderator
Cold Spring Harb Perspect Med. 2019 Dec 23. pii: a038612. doi: 10.1101/cshperspect.a038612. [Epub ahead of print] [h=1]Bat-Borne Influenza A Viruses: An Awakening.[/h]
Ciminski K[SUP]1,[/SUP][SUP]2[/SUP], Schwemmle M[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h] 1 Institute of Virology, Medical Center University of Freiburg, 79104 Freiburg, Germany. 2 Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
[h=3]Abstract[/h] Influenza A viruses (IAVs) originating from aquatic waterfowl recurrently cross interspecies barriers, which is greatly facilitated by utilizing cell surface-exposed monosaccharide sialic acids located on vertebrate cells as a universal host cell receptor. These glycan structures are first bound by the viral hemagglutinin (HA) for cell entry and then cleaved by the viral neuraminidase (NA) for particle release. In contrast, viruses of the recently identified bat-borne IAV subtypes H17N10 and H18N11 encode HA and NA homologs unable to interact with sialic acid residues despite a high degree of structural homology with their conventional counterparts. However, the most recent findings show that bat IAV HAs make use of the major histocompatibility complex class II proteins of different vertebrate species to gain entry into host cells, potentially permitting a broader host tropism. This review recapitulates current progress in the field of bat IAV research including the first assessment of the spillover potential of these bat viruses into other mammals.
Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31871229 DOI: 10.1101/cshperspect.a038612
Ciminski K[SUP]1,[/SUP][SUP]2[/SUP], Schwemmle M[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h] 1 Institute of Virology, Medical Center University of Freiburg, 79104 Freiburg, Germany. 2 Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
[h=3]Abstract[/h] Influenza A viruses (IAVs) originating from aquatic waterfowl recurrently cross interspecies barriers, which is greatly facilitated by utilizing cell surface-exposed monosaccharide sialic acids located on vertebrate cells as a universal host cell receptor. These glycan structures are first bound by the viral hemagglutinin (HA) for cell entry and then cleaved by the viral neuraminidase (NA) for particle release. In contrast, viruses of the recently identified bat-borne IAV subtypes H17N10 and H18N11 encode HA and NA homologs unable to interact with sialic acid residues despite a high degree of structural homology with their conventional counterparts. However, the most recent findings show that bat IAV HAs make use of the major histocompatibility complex class II proteins of different vertebrate species to gain entry into host cells, potentially permitting a broader host tropism. This review recapitulates current progress in the field of bat IAV research including the first assessment of the spillover potential of these bat viruses into other mammals.
Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31871229 DOI: 10.1101/cshperspect.a038612