tetano
Editor, Senior Moderator
Basic Res Cardiol. 2020 Apr 9;115(3):31. doi: 10.1007/s00395-020-0791-5.
COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?
Rizzo P[SUP]1,[/SUP][SUP]2[/SUP], Vieceli Dalla Sega F[SUP]3[/SUP], Fortini F[SUP]3[/SUP], Marracino L[SUP]4[/SUP], Rapezzi C[SUP]3,[/SUP][SUP]5[/SUP], Ferrari R[SUP]3,[/SUP][SUP]5[/SUP].
Author information
Abstract
From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.
KEYWORDS:
ADAM17; Angiotensin-converting enzyme 2; COVID-19; Cardiovascular disease; Coronavirus disease; Furin; Notch
PMID:32274570DOI:10.1007/s00395-020-0791-5
COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?
Rizzo P[SUP]1,[/SUP][SUP]2[/SUP], Vieceli Dalla Sega F[SUP]3[/SUP], Fortini F[SUP]3[/SUP], Marracino L[SUP]4[/SUP], Rapezzi C[SUP]3,[/SUP][SUP]5[/SUP], Ferrari R[SUP]3,[/SUP][SUP]5[/SUP].
Author information
Abstract
From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.
KEYWORDS:
ADAM17; Angiotensin-converting enzyme 2; COVID-19; Cardiovascular disease; Coronavirus disease; Furin; Notch
PMID:32274570DOI:10.1007/s00395-020-0791-5