tetano
Editor, Senior Moderator
Antiviral Res. 2014 Nov 10;113C:62-70. doi: 10.1016/j.antiviral.2014.11.003. [Epub ahead of print]
Baicalin inhibits autophagy induced by influenza A virus H3N2.
Zhu HY1, Han L1, Shi XL1, Wang BL1, Huang H1, Wang X1, Chen DF2, Ju DW1, Feng MQ3.
Author information
Abstract
Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Autophagy; Baicalin; H3N2; Influenza A virus
PMID:
25446340
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25446340
Baicalin inhibits autophagy induced by influenza A virus H3N2.
Zhu HY1, Han L1, Shi XL1, Wang BL1, Huang H1, Wang X1, Chen DF2, Ju DW1, Feng MQ3.
Author information
Abstract
Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Autophagy; Baicalin; H3N2; Influenza A virus
PMID:
25446340
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25446340