Bacterium can reverse autism-like behaviour in mice

[Emily]

http://www.nature.com/news/bacterium-can-reverse-autism-like-behaviour-in-mice-1.14308

Bacterium can reverse autism-like behaviour in mice

Findings support idea that gut microbiome has a role in disorder.

Sara Reardon

05 December 2013

http://www.cell.com/retrieve/pii/S0092867413014736

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Elaine Y. Hsiao, Sara W. McBride, Sophia Hsien, Gil Sharon, Embriette R. Hyde, Tyler McCue, Julian A. Codelli, Janet Chow, Sarah E. Reisman, Joseph F. Petrosino, Paul H. Patterson, Sarkis K. Mazmanian

Cell - 05 December 2013

• Highlights
• The MIA model recapitulates GI comorbidities linked to a subset of ASD individuals
• Targeting the microbiota treats specific GI and behavioral symptoms
• Gut microbes regulate metabolites that alter behavior in animals
• Microbiota may contribute to the pathophysiology of neurodevelopmental disorders