Mary Wilson
Well-known member
Jun 21, 2022
silcn opened this issue. 23 comments
Proposal for a sublineage of BA.2
Earliest sequence: 2022-06-02 (India)
Countries detected: India (5 seq, from 3 states)
Defining mutations:
S:K147E, W152R, F157L, I210V, G257S, D339H (mutated from G339D), G446S, N460K, R493Q (reversion)
ORF1a:S1221L, P1640S, N4060S
ORF1b:G662S
E:T11A
Don't think much needs to be said to explain why I'm proposing this. Very recent, long branch with 9 new spike mutations, detection in multiple states that aren't all close together (Maharashtra, Karnataka, Jammu and Kashmir). I expect quite a few people have been monitoring it
... We've added lineage BA.2.75 with 3 newly designated sequences. Defining mutation(s) A22001G (S:K147E), T22016C (S:W152R).
... Among the 20 new BA.2.75 uploads from Maharashtra today is an apparent outlier sequence, EPI_ISL_13502528, which has S:147E, 210V, 257S, 339H, 493Q and ORF1a:1221L but is missing the other defining mutations and instead has some more of its own (none in Spike though). It is classified as BA.2 rather than BA.2.75 by Usher. If this spreads then it could potentially deserve a separate designation
https://github.com/cov-lineages/pang...ion/issues/773
silcn opened this issue. 23 comments
Proposal for a sublineage of BA.2
Earliest sequence: 2022-06-02 (India)
Countries detected: India (5 seq, from 3 states)
Defining mutations:
S:K147E, W152R, F157L, I210V, G257S, D339H (mutated from G339D), G446S, N460K, R493Q (reversion)
ORF1a:S1221L, P1640S, N4060S
ORF1b:G662S
E:T11A
Don't think much needs to be said to explain why I'm proposing this. Very recent, long branch with 9 new spike mutations, detection in multiple states that aren't all close together (Maharashtra, Karnataka, Jammu and Kashmir). I expect quite a few people have been monitoring it
... We've added lineage BA.2.75 with 3 newly designated sequences. Defining mutation(s) A22001G (S:K147E), T22016C (S:W152R).
... Among the 20 new BA.2.75 uploads from Maharashtra today is an apparent outlier sequence, EPI_ISL_13502528, which has S:147E, 210V, 257S, 339H, 493Q and ORF1a:1221L but is missing the other defining mutations and instead has some more of its own (none in Spike though). It is classified as BA.2 rather than BA.2.75 by Usher. If this spreads then it could potentially deserve a separate designation
https://github.com/cov-lineages/pang...ion/issues/773