Mary Wilson
Well-known member
Sep 8, 2022
Description
Sub-lineage of:BA.2.3.2
Earliest sequence: 2022-08-20
Most recent sequence: 2022-08-23
Countries circulating: Vietnam
Genomes
hCoV-19/Japan/IC-13842/2022, EPI_ISL_14853710
hCoV-19/Japan/IC-14003/2022, EPI_ISL_14853827
hCoV-19/Japan/IC-14023/2022, EPI_ISL_14853841
Evidence
Despite the BA.5 Omicron variant recently becoming prevalent globally, we identified the other variant, BA.2.3.2-positive three entrants from Vietnam (Pango lineage3, version: 4.1.2), although the genome sequences exhibited additional mutation profiles: IC-13842 (collection date: 8/20/2022; GISAID ID: EPI_ISL_14853710), IC-14023 (collection date: 8/22/2022; GISAID ID: EPI_ISL_14853841), and IC-14003 (collection date: 8/23/2022; GISAID ID: EPI_ISL_14853827). The figure shows the number of BA.2.3.2 sequences deposited in GISAID from each country.
BA.2.3.2 in all subjects carried more than 90 nucleotide mutations that have not previously been detected in this variant (typical mutation frequency: 60–70) (Table), and shared many mutations, especially 1) mutations leading to common amino acid changes in the Spike protein, namely, Y144del, a three-amino-acid insertion at position 212 (ins_S:212:NGE), R346T, L452R, N460K, G476S, R493Q (reversion), and S640F; and 2) a frame shift by a deletion in open reading frame 6 (ORF6) (27266_27300del). ...
https://github.com/cov-lineages/pango-designation/issues/1052
Description
Sub-lineage of:BA.2.3.2
Earliest sequence: 2022-08-20
Most recent sequence: 2022-08-23
Countries circulating: Vietnam
Genomes
hCoV-19/Japan/IC-13842/2022, EPI_ISL_14853710
hCoV-19/Japan/IC-14003/2022, EPI_ISL_14853827
hCoV-19/Japan/IC-14023/2022, EPI_ISL_14853841
Evidence
Despite the BA.5 Omicron variant recently becoming prevalent globally, we identified the other variant, BA.2.3.2-positive three entrants from Vietnam (Pango lineage3, version: 4.1.2), although the genome sequences exhibited additional mutation profiles: IC-13842 (collection date: 8/20/2022; GISAID ID: EPI_ISL_14853710), IC-14023 (collection date: 8/22/2022; GISAID ID: EPI_ISL_14853841), and IC-14003 (collection date: 8/23/2022; GISAID ID: EPI_ISL_14853827). The figure shows the number of BA.2.3.2 sequences deposited in GISAID from each country.
BA.2.3.2 in all subjects carried more than 90 nucleotide mutations that have not previously been detected in this variant (typical mutation frequency: 60–70) (Table), and shared many mutations, especially 1) mutations leading to common amino acid changes in the Spike protein, namely, Y144del, a three-amino-acid insertion at position 212 (ins_S:212:NGE), R346T, L452R, N460K, G476S, R493Q (reversion), and S640F; and 2) a frame shift by a deletion in open reading frame 6 (ORF6) (27266_27300del). ...
https://github.com/cov-lineages/pango-designation/issues/1052