tetano
Editor, Senior Moderator
ACS Med Chem Lett. 2014 May 2;5(7):831-6. doi: 10.1021/ml500108s. eCollection 2014.
Azapropellanes with anti-influenza a virus activity.
Torres E1, Leiva R1, Gazzarrini S2, Rey-Carrizo M1, Frigol?-Vivas M1, Moroni A2, Naesens L3, V?zquez S1.
Author information
Abstract
The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
KEYWORDS:
Amantadine; M2 channel; hemagglutinin; influenza; propellane
PMID:
25050174
[PubMed]
PMCID:
PMC4094260
[Available on 2015/7/10]
http://www.ncbi.nlm.nih.gov/pubmed/25050174
Azapropellanes with anti-influenza a virus activity.
Torres E1, Leiva R1, Gazzarrini S2, Rey-Carrizo M1, Frigol?-Vivas M1, Moroni A2, Naesens L3, V?zquez S1.
Author information
Abstract
The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
KEYWORDS:
Amantadine; M2 channel; hemagglutinin; influenza; propellane
PMID:
25050174
[PubMed]
PMCID:
PMC4094260
[Available on 2015/7/10]
http://www.ncbi.nlm.nih.gov/pubmed/25050174