tetano
Editor, Senior Moderator
Avicenna J Med
. 2021 Nov 15;11(4):200-209.
doi: 10.1055/s-0041-1736540. eCollection 2021 Oct.
Fetal Complications in COVID-19 Infected Pregnant Woman: A Systematic Review and Meta-Analysis
Arjola Agolli[SUP] 1 [/SUP], Olsi Agolli[SUP] 1 [/SUP], Diana Fiorela Sánchez Velazco[SUP] 2 [/SUP], Md Ripon Ahammed[SUP] 3 [/SUP], Mehrie Patel[SUP] 1 [/SUP], Jose Cardona-Guzman[SUP] 4 [/SUP], Radhika Garimella[SUP] 5 [/SUP], Natcha Rummaneethorn[SUP] 6 [/SUP], Seema Bista[SUP] 1 [/SUP], Rafael Abreu[SUP] 4 [/SUP], Nikole Czapp[SUP] 4 [/SUP], Manuel Garcia[SUP] 4 [/SUP]
Affiliations
Abstract
Background Pregnancy is an immunocompromised state and, for this reason, a pregnant woman is at a higher risk of getting infected as compared with a healthy individual. There is limited data available regarding the impact of COVD-19 on pregnancy; however, the case of miscarriage due to placental infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in second trimester has already been reported. Methods We searched for all published articles in PubMed, Science Direct, Cochrane, Scopus, and Embase. The literature search produced 167 relevant publications; 67 manuscripts were further excluded because they did not satisfy our inclusion criteria. Out of the remaining 100 articles, 78 were excluded after full text screening. Therefore, a total of 22 articles were eligible for review in our study. Results Overall, these 22 studies included a total of 7,034 participants: 2,689 (38.23%) SARS-CoV-2 positive pregnant women, of which 2,578 (95.87%) were laboratory confirmed and 111 (4.13%) were clinically diagnosed. Among the positive patients, there were 174 (6.47%) cases of abortion, of them 168 (96.55%) were spontaneous abortions and 6 (3.45%) were missed. Most patients either reported mild symptoms of fever, cough, fatigue, and anosmia or they presented asymptomatic. Conclusion Additional investigation and rigorous research are warranted to confirm placental pathology mechanisms concerning COVID-19 to protect maternal and fetal health.
Keywords: COVID-19; abortion; coronavirus; pregnancy; pregnancy loss.
. 2021 Nov 15;11(4):200-209.
doi: 10.1055/s-0041-1736540. eCollection 2021 Oct.
Fetal Complications in COVID-19 Infected Pregnant Woman: A Systematic Review and Meta-Analysis
Arjola Agolli[SUP] 1 [/SUP], Olsi Agolli[SUP] 1 [/SUP], Diana Fiorela Sánchez Velazco[SUP] 2 [/SUP], Md Ripon Ahammed[SUP] 3 [/SUP], Mehrie Patel[SUP] 1 [/SUP], Jose Cardona-Guzman[SUP] 4 [/SUP], Radhika Garimella[SUP] 5 [/SUP], Natcha Rummaneethorn[SUP] 6 [/SUP], Seema Bista[SUP] 1 [/SUP], Rafael Abreu[SUP] 4 [/SUP], Nikole Czapp[SUP] 4 [/SUP], Manuel Garcia[SUP] 4 [/SUP]
Affiliations
- PMID: 34881203
- PMCID: PMC8648404
- DOI: 10.1055/s-0041-1736540
Abstract
Background Pregnancy is an immunocompromised state and, for this reason, a pregnant woman is at a higher risk of getting infected as compared with a healthy individual. There is limited data available regarding the impact of COVD-19 on pregnancy; however, the case of miscarriage due to placental infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in second trimester has already been reported. Methods We searched for all published articles in PubMed, Science Direct, Cochrane, Scopus, and Embase. The literature search produced 167 relevant publications; 67 manuscripts were further excluded because they did not satisfy our inclusion criteria. Out of the remaining 100 articles, 78 were excluded after full text screening. Therefore, a total of 22 articles were eligible for review in our study. Results Overall, these 22 studies included a total of 7,034 participants: 2,689 (38.23%) SARS-CoV-2 positive pregnant women, of which 2,578 (95.87%) were laboratory confirmed and 111 (4.13%) were clinically diagnosed. Among the positive patients, there were 174 (6.47%) cases of abortion, of them 168 (96.55%) were spontaneous abortions and 6 (3.45%) were missed. Most patients either reported mild symptoms of fever, cough, fatigue, and anosmia or they presented asymptomatic. Conclusion Additional investigation and rigorous research are warranted to confirm placental pathology mechanisms concerning COVID-19 to protect maternal and fetal health.
Keywords: COVID-19; abortion; coronavirus; pregnancy; pregnancy loss.