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Avian Pathol . Efficacy of a multi-clade inactivated recombinant vaccine against the circulating highly pathogenic influenza A/H5N1 of clade 2.3.4.4

tetano

tetano

Editor, Senior Moderator
Avian Pathol


. 2025 Nov 24:1-12.
doi: 10.1080/03079457.2025.2582672. Online ahead of print. Efficacy of a multi-clade inactivated recombinant vaccine against the circulating highly pathogenic influenza A/H5N1 of clade 2.3.4.4b in poultry

Wael M Elfeil[SUP] 1 [/SUP], Marwa Safwat[SUP] 2 [/SUP], Ahmed Sedeek[SUP] 2 [/SUP], Amany Adel[SUP] 2 [/SUP], Heba Hassan[SUP] 2 [/SUP], Mohamed A Zain El-Abideen[SUP] 2 [/SUP], Ibrahim Ali[SUP] 3 [/SUP], Islam Hisham[SUP] 2 [/SUP], Abdelsatar Arafa[SUP] 2 [/SUP], Abdullah Selim[SUP] 2 [/SUP], Manal Afifi[SUP] 4 5 [/SUP], Momtaz A Shaheen[SUP] 2 [/SUP], Magdy F Elkady[SUP] 6 [/SUP], Walid H Kilany[SUP] 2 [/SUP]



Affiliations
Abstract

Commercial inactivated vaccines improved the clinical picture of H5N1 in challenged birds.The developed vaccines induced protective antibody titres against HPAIV clade 2.3.4.4b within 4 weeks.The developed vaccines provided full protection against challenge by HPAIV clade 2.3.4.4b.The developed vaccines provided a significant reduction in virus shedding.

Keywords: H5N1; H5N8; HPAI; MEFLUVAC™; clade 2.3.4.4b; phylogenetic analysis; vaccine.

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