tetano
Editor, Senior Moderator
Br Med Bull. 2019 Dec 14. pii: ldz036. doi: 10.1093/bmb/ldz036. [Epub ahead of print] [h=1]Avian influenza viruses in humans: lessons from past outbreaks.[/h]
Li YT[SUP]1[/SUP], Linster M[SUP]1[/SUP], Mendenhall IH[SUP]1[/SUP], Su YCF[SUP]1[/SUP], Smith GJD[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h] 1 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857. 2 SingHealth Duke-NUS Global Health Institute, 31 Third Hospital Ave, Singapore 168753. 3 Duke Global Health Institute, Duke University, 310 Trent Drive, Durham, NC 27710, USA.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Human infections with avian influenza viruses (AIV) represent a persistent public health threat. The principal risk factor governing human infection with AIV is from direct contact with infected poultry and is primarily observed in Asia and Egypt where live-bird markets are common.
[h=4]AREAS OF AGREEMENT:[/h] Changing patterns of virus transmission and a lack of obvious disease manifestations in avian species hampers early detection and efficient control of potentially zoonotic AIV.
[h=4]AREAS OF CONTROVERSY:[/h] Despite extensive studies on biological and environmental risk factors, the exact conditions required for cross-species transmission from avian species to humans remain largely unknown.
[h=4]GROWING POINTS:[/h] The development of a universal ('across-subtype') influenza vaccine and effective antiviral therapeutics are a priority.
[h=4]AREAS TIMELY FOR DEVELOPING RESEARCH:[/h] Sustained virus surveillance and collection of ecological and physiological parameters from birds in different environments is required to better understand influenza virus ecology and identify risk factors for human infection.
? The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] highly pathogenic avian influenza virus; live-bird markets; pandemics; virus ecology; virus spillover; zoonotic viruses
PMID: 31848585 DOI: 10.1093/bmb/ldz036
Li YT[SUP]1[/SUP], Linster M[SUP]1[/SUP], Mendenhall IH[SUP]1[/SUP], Su YCF[SUP]1[/SUP], Smith GJD[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h] 1 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857. 2 SingHealth Duke-NUS Global Health Institute, 31 Third Hospital Ave, Singapore 168753. 3 Duke Global Health Institute, Duke University, 310 Trent Drive, Durham, NC 27710, USA.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Human infections with avian influenza viruses (AIV) represent a persistent public health threat. The principal risk factor governing human infection with AIV is from direct contact with infected poultry and is primarily observed in Asia and Egypt where live-bird markets are common.
[h=4]AREAS OF AGREEMENT:[/h] Changing patterns of virus transmission and a lack of obvious disease manifestations in avian species hampers early detection and efficient control of potentially zoonotic AIV.
[h=4]AREAS OF CONTROVERSY:[/h] Despite extensive studies on biological and environmental risk factors, the exact conditions required for cross-species transmission from avian species to humans remain largely unknown.
[h=4]GROWING POINTS:[/h] The development of a universal ('across-subtype') influenza vaccine and effective antiviral therapeutics are a priority.
[h=4]AREAS TIMELY FOR DEVELOPING RESEARCH:[/h] Sustained virus surveillance and collection of ecological and physiological parameters from birds in different environments is required to better understand influenza virus ecology and identify risk factors for human infection.
? The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] highly pathogenic avian influenza virus; live-bird markets; pandemics; virus ecology; virus spillover; zoonotic viruses
PMID: 31848585 DOI: 10.1093/bmb/ldz036