Commonground
Senior Moderator
Avian influenza virus polymerase structure of significant progress in the field of research
2008-7-17 16:39:38
China's scientific and technological personnel in the international community take the lead in revealing the avian flu virus polymerase key part of PA and PB1 subunit peptide complex three-dimensional structure of the fine, fill the bird flu virus polymerase structure of the blank areas of study. This structure of the analysis, to study the avian flu virus from replicating, and to design anti-influenza drugs available to provide a real model. July 9, the international authoritative journal "Nature" ( "Nature") published online by the Chinese Academy of Sciences researcher at the Institute of Biophysics, Liu Yingfang leadership of the research team, and Raozi Nankai University, Nankai University and academician of the leadership - Tsinghua University -- Biophysical by the Joint Study Group co-completed the study.
In recent years, by the H5N1 subtype of avian influenza virus caused the epidemic on the health of the global human major threat. Because the virus constantly changes in the development of new anti-influenza drug has become a world scientific community is critical for a major research topic. Among them, and reveal the avian flu virus closely related to the three-dimensional structure of protein not only to clarify the avian flu virus replication mechanism is an important scientific significance, but also for the development of anti-flu drugs has an important value.
Liu Yingfang researcher said that the avian influenza virus genome contains eight RNA fragments, known to be protein-coding 11. Which, by the PA, PB1, and PB2 subunit of the three components of the polymerase complex is responsible for the virus genome RNA virus replication and mRNA transcription of key components, and because of its highly conservative, low mutation rate, as anti-bird Flu virus an important target for drug design. The study concluded that over the years, PB1 virus RNA polymerase is the catalytic subunit, is responsible for the RNA virus replication and transcription; PB2 is responsible for a called "Snatch", to take the CAP host mRNA cap structure for the virus mRNA Transcription and the PA subunit not only involved in the replication of the virus, but also a cut in the DNA activity, protease activity, participation virus RNA transcription, the virus particle assembly, and other activities of the virus, thus polymerase complex in the entire study Is particularly important.
The researchers used new ideas and analysis of the PA and PB1-peptide-protein complex in the 2.9-Egyptian resolution crystal structure - clearly shows that the PA and PB1 peptide interaction patterns, and found the role of the amino acid sites In the avian flu virus-highly conservative, and this broad-spectrum anti-influenza (including human influenza and avian influenza) drugs provide an ideal target proteins. At the same time, researchers under the complex structure, and some of the known protein mutant research findings, the PA to speculate polymerase subunits in the role, function to further study the molecular basis of the provision.
http://www.tech-food.com/news/2008-7-17/n0192269.htm
2008-7-17 16:39:38
China's scientific and technological personnel in the international community take the lead in revealing the avian flu virus polymerase key part of PA and PB1 subunit peptide complex three-dimensional structure of the fine, fill the bird flu virus polymerase structure of the blank areas of study. This structure of the analysis, to study the avian flu virus from replicating, and to design anti-influenza drugs available to provide a real model. July 9, the international authoritative journal "Nature" ( "Nature") published online by the Chinese Academy of Sciences researcher at the Institute of Biophysics, Liu Yingfang leadership of the research team, and Raozi Nankai University, Nankai University and academician of the leadership - Tsinghua University -- Biophysical by the Joint Study Group co-completed the study.
In recent years, by the H5N1 subtype of avian influenza virus caused the epidemic on the health of the global human major threat. Because the virus constantly changes in the development of new anti-influenza drug has become a world scientific community is critical for a major research topic. Among them, and reveal the avian flu virus closely related to the three-dimensional structure of protein not only to clarify the avian flu virus replication mechanism is an important scientific significance, but also for the development of anti-flu drugs has an important value.
Liu Yingfang researcher said that the avian influenza virus genome contains eight RNA fragments, known to be protein-coding 11. Which, by the PA, PB1, and PB2 subunit of the three components of the polymerase complex is responsible for the virus genome RNA virus replication and mRNA transcription of key components, and because of its highly conservative, low mutation rate, as anti-bird Flu virus an important target for drug design. The study concluded that over the years, PB1 virus RNA polymerase is the catalytic subunit, is responsible for the RNA virus replication and transcription; PB2 is responsible for a called "Snatch", to take the CAP host mRNA cap structure for the virus mRNA Transcription and the PA subunit not only involved in the replication of the virus, but also a cut in the DNA activity, protease activity, participation virus RNA transcription, the virus particle assembly, and other activities of the virus, thus polymerase complex in the entire study Is particularly important.
The researchers used new ideas and analysis of the PA and PB1-peptide-protein complex in the 2.9-Egyptian resolution crystal structure - clearly shows that the PA and PB1 peptide interaction patterns, and found the role of the amino acid sites In the avian flu virus-highly conservative, and this broad-spectrum anti-influenza (including human influenza and avian influenza) drugs provide an ideal target proteins. At the same time, researchers under the complex structure, and some of the known protein mutant research findings, the PA to speculate polymerase subunits in the role, function to further study the molecular basis of the provision.
http://www.tech-food.com/news/2008-7-17/n0192269.htm