tetano
Editor, Senior Moderator
J Infect Dis. 2016 Mar 30. pii: jiw126. [Epub ahead of print]
[h=1]Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination.[/h] Crabtree JN[SUP]1[/SUP], He W[SUP]2[/SUP], Guan W[SUP]3[/SUP], Flage M[SUP]4[/SUP], Miller MS[SUP]5[/SUP], Peterson EJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] High-affinity antibody production, T cell activation, and Interferon upregulation all contribute to protective immunity that occurs in humans following influenza immunization. Hematopoietic cell-specificPTPN22encodes Lymphoid Phosphatase (Lyp), which regulates lymphocyte antigen receptor and Pattern Recognition Receptor (PRR) signaling. APTPN22variant R620W (LypW) predisposes to autoimmune and infectious disease, and confers altered signaling through antigen receptors and PRRs. We tested the hypothesis that LypW-bearing humans would have diminished immune response to trivalent influenza vaccine (TIV). LypW carriers exhibited decreased induction of influenza-specific CD4 T cells expressing effector cytokines, and failed to increase antibody affinity following TIV. No differences between LypW carriers and non-carriers were observed in virus-specific CD8 T cell responses, early interferon transcriptional responses, or myeloid APC costimulatory molecule upregulation. LypW association with defects in TIV-induced CD4 T cell expansion and antibody affinity maturation suggests that LypW may predispose to diminished capacity to generate protective immunity against influenza.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27034343 [PubMed - as supplied by publisher]
[h=1]Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination.[/h] Crabtree JN[SUP]1[/SUP], He W[SUP]2[/SUP], Guan W[SUP]3[/SUP], Flage M[SUP]4[/SUP], Miller MS[SUP]5[/SUP], Peterson EJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] High-affinity antibody production, T cell activation, and Interferon upregulation all contribute to protective immunity that occurs in humans following influenza immunization. Hematopoietic cell-specificPTPN22encodes Lymphoid Phosphatase (Lyp), which regulates lymphocyte antigen receptor and Pattern Recognition Receptor (PRR) signaling. APTPN22variant R620W (LypW) predisposes to autoimmune and infectious disease, and confers altered signaling through antigen receptors and PRRs. We tested the hypothesis that LypW-bearing humans would have diminished immune response to trivalent influenza vaccine (TIV). LypW carriers exhibited decreased induction of influenza-specific CD4 T cells expressing effector cytokines, and failed to increase antibody affinity following TIV. No differences between LypW carriers and non-carriers were observed in virus-specific CD8 T cell responses, early interferon transcriptional responses, or myeloid APC costimulatory molecule upregulation. LypW association with defects in TIV-induced CD4 T cell expansion and antibody affinity maturation suggests that LypW may predispose to diminished capacity to generate protective immunity against influenza.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27034343 [PubMed - as supplied by publisher]