tetano
Editor, Senior Moderator
J Infect Dis. 2019 May 21. pii: jiz270. doi: 10.1093/infdis/jiz270. [Epub ahead of print]
[h=1]Association of severe influenza virus infections with CD226 (DNAM-1) variants.[/h] Redlberger-Fritz M[SUP]1[/SUP], Vietzen H[SUP]1[/SUP], Puchhammer-St?ckl E[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] NK-cell response against influenza viruses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1). We analyzed whether distinct CD226 variants are associated with influenza disease severity. Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that especially presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (p=0.0076). Also a higher frequency of the rs727088 G allele and rs763361 T allele were observed in the ICU group. Thus, CD226 variants may contribute to the severity of influenza virus disease.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] CD226; CD226 and influenza; CD226 variants and disease severity; severe influenza
PMID: 31114873 DOI: 10.1093/infdis/jiz270
[h=1]Association of severe influenza virus infections with CD226 (DNAM-1) variants.[/h] Redlberger-Fritz M[SUP]1[/SUP], Vietzen H[SUP]1[/SUP], Puchhammer-St?ckl E[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] NK-cell response against influenza viruses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1). We analyzed whether distinct CD226 variants are associated with influenza disease severity. Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that especially presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (p=0.0076). Also a higher frequency of the rs727088 G allele and rs763361 T allele were observed in the ICU group. Thus, CD226 variants may contribute to the severity of influenza virus disease.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] CD226; CD226 and influenza; CD226 variants and disease severity; severe influenza
PMID: 31114873 DOI: 10.1093/infdis/jiz270