tetano
Editor, Senior Moderator
Clin Infect Dis. 2019 Sep 28. pii: ciz968. doi: 10.1093/cid/ciz968. [Epub ahead of print] [h=1]Association between the respiratory microbiome and susceptibility to influenza virus infection.[/h]
Tsang TK[SUP]1[/SUP], Lee KH[SUP]2[/SUP], Foxman B[SUP]2[/SUP], Balmaseda A[SUP]3,[/SUP][SUP]4[/SUP], Gresh L[SUP]3[/SUP], Sanchez N[SUP]3[/SUP], Ojeda S[SUP]3[/SUP], Lopez R[SUP]3,[/SUP][SUP]4[/SUP], Yang Y[SUP]1,[/SUP][SUP]5[/SUP], Kuan G[SUP]6[/SUP], Gordon A[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Biostatistics, University of Florida, Gainesville, FL, USA. 2 Department of Epidemiology, School of Public Health, University of Michigan, MI, USA. 3 Sustainable Sciences Institute, Managua, Nicaragua. 4 Laboratorio Nacional de Virolog?a, Centro Nacional de Diagn?stico y Referencia, Ministry of Health, Managua, Nicaragua. 5 Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. 6 Centro de Salud S?crates Flores Vivas, Ministry of Health, Managua, Nicaragua.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Previous studies suggest that the nose/throat microbiome may play an important role in shaping host immunity and modifying the risk of respiratory infection. Our aim is to quantify the association between the nose/throat microbiome and susceptibility to influenza virus infection.
[h=4]METHODS:[/h] In this household transmission study, index cases with confirmed influenza virus infection and their household contacts were followed for 9-12 days to identify secondary influenza infections. Respiratory swabs were collected at enrollment to identify and quantify bacterial species via high- performance sequencing. Data were analyzed by an individual hazard-based transmission model that was adjusted for age, vaccination, and household size.
[h=4]RESULTS:[/h] We recruited 115 index cases with influenza A(H3N2) or B infection, and 436 household contacts. We estimated that a 10-fold increase in the abundance in Streptococcus spp. and Prevotella salivae was associated with 48% (95% CI: 9%, 69%) and 25% (95% CI: 0.5%, 42%) lower susceptibility to influenza A(H3N2) infection, respectively. By contrast, for influenza B infection, a 10-fold increase in the abundance in Streptococcus vestibularis and Prevotella spp. was associated with 63% (95% CI: 17%, 83%) lower and 83% (95% CI: 15%, 210%) higher susceptibility, respectively.
[h=4]CONCLUSIONS:[/h] Susceptibility to influenza infection is associated with the nose/throat microbiome at the time of exposure. The effects of oligotypes on susceptibility differ between influenza A(H3N2) and B viruses. Our results suggest that microbiome may be a useful predictor of susceptibility, with the implication that microbiome could be modulated to reduce influenza infection risk, should these associations be causal.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] influenza; microbiome; susceptibility; transmission
PMID: 31562814 DOI: 10.1093/cid/ciz968
Tsang TK[SUP]1[/SUP], Lee KH[SUP]2[/SUP], Foxman B[SUP]2[/SUP], Balmaseda A[SUP]3,[/SUP][SUP]4[/SUP], Gresh L[SUP]3[/SUP], Sanchez N[SUP]3[/SUP], Ojeda S[SUP]3[/SUP], Lopez R[SUP]3,[/SUP][SUP]4[/SUP], Yang Y[SUP]1,[/SUP][SUP]5[/SUP], Kuan G[SUP]6[/SUP], Gordon A[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Biostatistics, University of Florida, Gainesville, FL, USA. 2 Department of Epidemiology, School of Public Health, University of Michigan, MI, USA. 3 Sustainable Sciences Institute, Managua, Nicaragua. 4 Laboratorio Nacional de Virolog?a, Centro Nacional de Diagn?stico y Referencia, Ministry of Health, Managua, Nicaragua. 5 Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. 6 Centro de Salud S?crates Flores Vivas, Ministry of Health, Managua, Nicaragua.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Previous studies suggest that the nose/throat microbiome may play an important role in shaping host immunity and modifying the risk of respiratory infection. Our aim is to quantify the association between the nose/throat microbiome and susceptibility to influenza virus infection.
[h=4]METHODS:[/h] In this household transmission study, index cases with confirmed influenza virus infection and their household contacts were followed for 9-12 days to identify secondary influenza infections. Respiratory swabs were collected at enrollment to identify and quantify bacterial species via high- performance sequencing. Data were analyzed by an individual hazard-based transmission model that was adjusted for age, vaccination, and household size.
[h=4]RESULTS:[/h] We recruited 115 index cases with influenza A(H3N2) or B infection, and 436 household contacts. We estimated that a 10-fold increase in the abundance in Streptococcus spp. and Prevotella salivae was associated with 48% (95% CI: 9%, 69%) and 25% (95% CI: 0.5%, 42%) lower susceptibility to influenza A(H3N2) infection, respectively. By contrast, for influenza B infection, a 10-fold increase in the abundance in Streptococcus vestibularis and Prevotella spp. was associated with 63% (95% CI: 17%, 83%) lower and 83% (95% CI: 15%, 210%) higher susceptibility, respectively.
[h=4]CONCLUSIONS:[/h] Susceptibility to influenza infection is associated with the nose/throat microbiome at the time of exposure. The effects of oligotypes on susceptibility differ between influenza A(H3N2) and B viruses. Our results suggest that microbiome may be a useful predictor of susceptibility, with the implication that microbiome could be modulated to reduce influenza infection risk, should these associations be causal.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] influenza; microbiome; susceptibility; transmission
PMID: 31562814 DOI: 10.1093/cid/ciz968