tetano
Editor, Senior Moderator
Virus Res. 2014 Sep 5. pii: S0168-1702(14)00347-5. doi: 10.1016/j.virusres.2014.08.019. [Epub ahead of print]
Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro.
Hillaire ML1, van Eijk M2, Vogelzang-van Trierum SE1, Nieuwkoop NJ1, van Riel D1, Fouchier RA1, Kuiken T1, Osterhaus AD3, Haagsman HP2, Rimmelzwaan GF4.
Author information
Abstract
The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, there is an urgent need for the development of novel classes of antiviral drugs. Here we investigated the antiviral properties of recombinant porcine surfactant protein D (RpSP-D), an innate defense molecule with lectin properties, against influenza B viruses. We have previously shown that porcine SP-D has more potent neutralizing activity against influenza A viruses than human SP-D. Here we show that RpSP-D neutralizes influenza B viruses efficiently and inhibited the binding of these viruses to epithelial cells of the human trachea.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
antiviral; influenza; surfactant protein D
PMID:
25200748
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25200748
Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro.
Hillaire ML1, van Eijk M2, Vogelzang-van Trierum SE1, Nieuwkoop NJ1, van Riel D1, Fouchier RA1, Kuiken T1, Osterhaus AD3, Haagsman HP2, Rimmelzwaan GF4.
Author information
Abstract
The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, there is an urgent need for the development of novel classes of antiviral drugs. Here we investigated the antiviral properties of recombinant porcine surfactant protein D (RpSP-D), an innate defense molecule with lectin properties, against influenza B viruses. We have previously shown that porcine SP-D has more potent neutralizing activity against influenza A viruses than human SP-D. Here we show that RpSP-D neutralizes influenza B viruses efficiently and inhibited the binding of these viruses to epithelial cells of the human trachea.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
antiviral; influenza; surfactant protein D
PMID:
25200748
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25200748