tetano
Editor, Senior Moderator
J Pediatric Infect Dis Soc. 2016 Jun 14. pii: piw028. [Epub ahead of print]
[h=1]Assessing Fever Frequency After Pediatric Live Attenuated Versus Inactivated Influenza Vaccination.[/h] Stockwell MS[SUP]1[/SUP], Broder KR[SUP]2[/SUP], Lewis P[SUP]2[/SUP], Jakob K[SUP]3[/SUP], Iqbal S[SUP]2[/SUP], Fernandez N[SUP]3[/SUP], Sharma D[SUP]2[/SUP], Barrett A[SUP]3[/SUP], LaRussa P[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OF KEY POINTS:[/h] The frequencies of fever in young children after live attenuated influenza versus inactivated influenza vaccine were low during the 2013-2014 influenza season and did not differ among vaccine types. Results from text message-only data were similar to those from all sources.
[h=4]BACKGROUND:[/h] Some studies have found a higher frequency of fever with trivalent live attenuated influenza vaccine (LAIV) than with inactivated influenza vaccine (IIV), but quadrivalent LAIV has not been assessed. Understanding fever is important for safety reviews and for parents and providers. In addition, there have been only a limited number of studies in which text messaging was used for vaccine adverse-event (AE) surveillance.
[h=4]METHODS:[/h] We conducted a prospective observational study in 3 community clinics in New York City to assess post-influenza vaccination fever in 24- to 59-month-olds during the 2013-2014 season. Enrolled families of children who received quadrivalent LAIV (LAIV4) or IIV (trivalent IIV3 or quadrivalent IIV4) replied to text messages that assessed their temperature on vaccination night and the next 10 nights (days 0 to 10); missing data were collected via telephone and a diary. We compared frequencies of fever (temperature ≥ 100.4?F) according to vaccine group on days 0 to 2 and 3 to 10 by using χ[SUP]2[/SUP] and multivariate log-binomial regression adjusted for age, previous influenza vaccination, and vaccine coadministration. We also assessed outcomes using all sources versus only text messages.
[h=4]RESULTS:[/h] Most (84.1% [n = 540]) eligible parents enrolled. Fever frequencies on days 0 to 2 did not differ between LAIV4 and any IIV (3.8% vs 5.7%, respectively; adjusted relative risk [aRR] [95% confidence interval], 0.60 [0.25-1.46]), between LAIV4 and IIV4 (4.2% vs 7.1%, respectively; aRR, 0.58 [0.19-1.72]), or between IIV4 and IIV3 (7.1% vs 6.0%, respectively; aRR, 1.02 [0.30-3.46]). The findings were similar when all data sources versus text-message data alone were used. There were no significant differences on days 3 to 10.
[h=4]CONCLUSIONS:[/h] Postvaccination fever frequencies were low overall and did not differ according to influenza vaccine type during the 2013-2014 influenza season. The similarity of results when data were limited to text messages lends support to its use for surveillance of vaccine adverse events.
? The Author 2016. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] fever; influenza; live attenuated; text message; vaccination; vaccine safety
PMID: 27302328 [PubMed - as supplied by publisher]
[h=1]Assessing Fever Frequency After Pediatric Live Attenuated Versus Inactivated Influenza Vaccination.[/h] Stockwell MS[SUP]1[/SUP], Broder KR[SUP]2[/SUP], Lewis P[SUP]2[/SUP], Jakob K[SUP]3[/SUP], Iqbal S[SUP]2[/SUP], Fernandez N[SUP]3[/SUP], Sharma D[SUP]2[/SUP], Barrett A[SUP]3[/SUP], LaRussa P[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OF KEY POINTS:[/h] The frequencies of fever in young children after live attenuated influenza versus inactivated influenza vaccine were low during the 2013-2014 influenza season and did not differ among vaccine types. Results from text message-only data were similar to those from all sources.
[h=4]BACKGROUND:[/h] Some studies have found a higher frequency of fever with trivalent live attenuated influenza vaccine (LAIV) than with inactivated influenza vaccine (IIV), but quadrivalent LAIV has not been assessed. Understanding fever is important for safety reviews and for parents and providers. In addition, there have been only a limited number of studies in which text messaging was used for vaccine adverse-event (AE) surveillance.
[h=4]METHODS:[/h] We conducted a prospective observational study in 3 community clinics in New York City to assess post-influenza vaccination fever in 24- to 59-month-olds during the 2013-2014 season. Enrolled families of children who received quadrivalent LAIV (LAIV4) or IIV (trivalent IIV3 or quadrivalent IIV4) replied to text messages that assessed their temperature on vaccination night and the next 10 nights (days 0 to 10); missing data were collected via telephone and a diary. We compared frequencies of fever (temperature ≥ 100.4?F) according to vaccine group on days 0 to 2 and 3 to 10 by using χ[SUP]2[/SUP] and multivariate log-binomial regression adjusted for age, previous influenza vaccination, and vaccine coadministration. We also assessed outcomes using all sources versus only text messages.
[h=4]RESULTS:[/h] Most (84.1% [n = 540]) eligible parents enrolled. Fever frequencies on days 0 to 2 did not differ between LAIV4 and any IIV (3.8% vs 5.7%, respectively; adjusted relative risk [aRR] [95% confidence interval], 0.60 [0.25-1.46]), between LAIV4 and IIV4 (4.2% vs 7.1%, respectively; aRR, 0.58 [0.19-1.72]), or between IIV4 and IIV3 (7.1% vs 6.0%, respectively; aRR, 1.02 [0.30-3.46]). The findings were similar when all data sources versus text-message data alone were used. There were no significant differences on days 3 to 10.
[h=4]CONCLUSIONS:[/h] Postvaccination fever frequencies were low overall and did not differ according to influenza vaccine type during the 2013-2014 influenza season. The similarity of results when data were limited to text messages lends support to its use for surveillance of vaccine adverse events.
? The Author 2016. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] fever; influenza; live attenuated; text message; vaccination; vaccine safety
PMID: 27302328 [PubMed - as supplied by publisher]