tetano
Editor, Senior Moderator
Asia Pac J Public Health
. 2025 Aug 9:10105395251360136.
doi: 10.1177/10105395251360136. Online ahead of print. Preparing for Future Pandemics: Vaccine Effectiveness Against SARS-CoV-2 Variant in a High-Risk Hospital Environment-A Case Study From Vietnam
Hien Thi Nguyen[SUP] 1 2 [/SUP], Luong Huy Duong[SUP] 3 [/SUP], Thai Quang Pham[SUP] 1 4 [/SUP], Than Huu Dao[SUP] 5 [/SUP], Kieu-Anh Thi Nguyen[SUP] 5 [/SUP], Huyen Thi Nguyen[SUP] 1 2 [/SUP], Nghia Duy Ngu[SUP] 1 [/SUP], Duong Nhu Tran[SUP] 6 [/SUP], Kim-Nhung Thi Le[SUP] 7 [/SUP], Tung Son Trinh[SUP] 8 [/SUP], H Rogier van Doorn[SUP] 8 [/SUP], Florian Vogt[SUP] 2 9 [/SUP], Khanh Cong Nguyen[SUP] 1 10 [/SUP]
Affiliations
On 30 September 2021, Viet Duc University Hospital in Northern Vietnam, reported a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta outbreak, leading to an 18-day lockdown and repeated testing of all on-site individuals. At this time, SARS-CoV-2 was not yet circulating at scale among the general public and COVID-19 vaccination status varied among staff, patients, and caregivers. We estimated vaccine effectiveness (VE), attack rates (ARs), and adjusted risk ratios (aRRs) to identify factors associated with infection among infection-naïve patients, caregivers, and staff using multivariable regression analysis. Among 630 at-risk individuals, there were 131 (21%) polymerase chain reaction (PCR)-confirmed COVID-19 cases including three deaths. The overall VE was 78% (95% confidence interval [CI]: 59-88; P < .05). Hospital staff (aRR 0.20; 95% CI: 0.09-0.42) and people who were fully vaccinated (aRR 0.51; 95% CI: 0.28-0.95) had a significantly lower risk of SARS-CoV-2 infection (P < .05). Our analysis shows the importance of being fully vaccinated in reducing the risk of SARS-CoV-2 infection in hospital settings.
Keywords: SARS-CoV-2; health care-associated infections; hospital; nosocomial infections; vaccine effectiveness.
. 2025 Aug 9:10105395251360136.
doi: 10.1177/10105395251360136. Online ahead of print. Preparing for Future Pandemics: Vaccine Effectiveness Against SARS-CoV-2 Variant in a High-Risk Hospital Environment-A Case Study From Vietnam
Hien Thi Nguyen[SUP] 1 2 [/SUP], Luong Huy Duong[SUP] 3 [/SUP], Thai Quang Pham[SUP] 1 4 [/SUP], Than Huu Dao[SUP] 5 [/SUP], Kieu-Anh Thi Nguyen[SUP] 5 [/SUP], Huyen Thi Nguyen[SUP] 1 2 [/SUP], Nghia Duy Ngu[SUP] 1 [/SUP], Duong Nhu Tran[SUP] 6 [/SUP], Kim-Nhung Thi Le[SUP] 7 [/SUP], Tung Son Trinh[SUP] 8 [/SUP], H Rogier van Doorn[SUP] 8 [/SUP], Florian Vogt[SUP] 2 9 [/SUP], Khanh Cong Nguyen[SUP] 1 10 [/SUP]
Affiliations
- PMID: 40782037
- DOI: 10.1177/10105395251360136
On 30 September 2021, Viet Duc University Hospital in Northern Vietnam, reported a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta outbreak, leading to an 18-day lockdown and repeated testing of all on-site individuals. At this time, SARS-CoV-2 was not yet circulating at scale among the general public and COVID-19 vaccination status varied among staff, patients, and caregivers. We estimated vaccine effectiveness (VE), attack rates (ARs), and adjusted risk ratios (aRRs) to identify factors associated with infection among infection-naïve patients, caregivers, and staff using multivariable regression analysis. Among 630 at-risk individuals, there were 131 (21%) polymerase chain reaction (PCR)-confirmed COVID-19 cases including three deaths. The overall VE was 78% (95% confidence interval [CI]: 59-88; P < .05). Hospital staff (aRR 0.20; 95% CI: 0.09-0.42) and people who were fully vaccinated (aRR 0.51; 95% CI: 0.28-0.95) had a significantly lower risk of SARS-CoV-2 infection (P < .05). Our analysis shows the importance of being fully vaccinated in reducing the risk of SARS-CoV-2 infection in hospital settings.
Keywords: SARS-CoV-2; health care-associated infections; hospital; nosocomial infections; vaccine effectiveness.