http://www.scielo.br/pdf/clin/v66n6/02.pdf
free full text at the link
CLINICAL SCIENCE
Follow-up after acute respiratory distress syndrome
caused by influenza a (H1N1) virus infection
Carlos Toufen Jr.,
I
Eduardo Leite V. Costa,
I
Adriana Sayuri Hirota,
III
Ho Yeh Li,
II
Marcelo Brito Passos
Amato,
II
Carlos Roberto Ribeiro Carvalho
I
I
Pulmonary Division ? InCor ? Faculdade de Medicina da Universidade de Sa
̃o Paulo, SP, Brazil.
II
Infectious and Parasitic Diseases Division ? Faculdade de
Medicina da Universidade de Sa
̃o Paulo, SP, Brazil.
III
Physiotherapy Service ? Instituto Central do Hospital das Cl
ı
́
nicas da Faculdade de Medicina da
Universidade de Sa
̃o Paulo, SP, Brazil.
BACKGROUND:
There are no reports on the long-term follow-up of patients with swine-origin influenza A virus
infection that progressed to acute respiratory distress syndrome.
METHODS:
Four patients were prospectively followed up with pulmonary function tests and high-resolution
computed tomography for six months after admission to an intensive care unit.
RESULTS:
Pulmonary function test results assessed two months after admission to the intensive care unit showed
reduced forced vital capacity in all patients and low diffusion capacity for carbon monoxide in two patients. At six
months, pulmonary function test results were available for three patients. Two patients continued to have a
restrictive pattern, and none of the patients presented with abnormal diffusion capacity for carbon monoxide. All
of them had a diffuse ground-glass pattern on high-resolution computed tomography that improved after six
months.
CONCLUSIONS:
Despite the marked severity of lung disease at admission, patients with acute respiratory distress
syndrome caused by swine-origin influenza A virus infection presented a late but substantial recovery over six
months of follow-up.
free full text at the link
CLINICAL SCIENCE
Follow-up after acute respiratory distress syndrome
caused by influenza a (H1N1) virus infection
Carlos Toufen Jr.,
I
Eduardo Leite V. Costa,
I
Adriana Sayuri Hirota,
III
Ho Yeh Li,
II
Marcelo Brito Passos
Amato,
II
Carlos Roberto Ribeiro Carvalho
I
I
Pulmonary Division ? InCor ? Faculdade de Medicina da Universidade de Sa
̃o Paulo, SP, Brazil.
II
Infectious and Parasitic Diseases Division ? Faculdade de
Medicina da Universidade de Sa
̃o Paulo, SP, Brazil.
III
Physiotherapy Service ? Instituto Central do Hospital das Cl
ı
́
nicas da Faculdade de Medicina da
Universidade de Sa
̃o Paulo, SP, Brazil.
BACKGROUND:
There are no reports on the long-term follow-up of patients with swine-origin influenza A virus
infection that progressed to acute respiratory distress syndrome.
METHODS:
Four patients were prospectively followed up with pulmonary function tests and high-resolution
computed tomography for six months after admission to an intensive care unit.
RESULTS:
Pulmonary function test results assessed two months after admission to the intensive care unit showed
reduced forced vital capacity in all patients and low diffusion capacity for carbon monoxide in two patients. At six
months, pulmonary function test results were available for three patients. Two patients continued to have a
restrictive pattern, and none of the patients presented with abnormal diffusion capacity for carbon monoxide. All
of them had a diffuse ground-glass pattern on high-resolution computed tomography that improved after six
months.
CONCLUSIONS:
Despite the marked severity of lung disease at admission, patients with acute respiratory distress
syndrome caused by swine-origin influenza A virus infection presented a late but substantial recovery over six
months of follow-up.