Giuseppe
Emeritus
Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. (Arch Virol., abstract, edited)
3. Arch Virol. 2010;155(1):83-7. Epub 2009 Nov 20.
Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.
Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. - Department of Medicine, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Room S-114, Baltimore, MD 21201, USA.
Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
PMID: 19936613 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Secondary Source ID, Grant Support
Publication Types:
* Research Support, N.I.H., Extramural
MeSH Terms:
* Evolution, Molecular*
* Genome, Viral*
* Humans
* Molecular Sequence Data
* Phylogeny
* Picornaviridae Infections/virology*
* Respiratory Tract Infections/virology*
* Rhinovirus/classification*
* Rhinovirus/genetics*
* Rhinovirus/isolation & purification
Secondary Source ID:
* GENBANK/GQ415051
* GENBANK/GQ415052
Grant Support:
* HL071609/HL/NHLBI NIH HHS/United States
-
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3. Arch Virol. 2010;155(1):83-7. Epub 2009 Nov 20.
Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.
Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. - Department of Medicine, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Room S-114, Baltimore, MD 21201, USA.
Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
PMID: 19936613 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Secondary Source ID, Grant Support
Publication Types:
* Research Support, N.I.H., Extramural
MeSH Terms:
* Evolution, Molecular*
* Genome, Viral*
* Humans
* Molecular Sequence Data
* Phylogeny
* Picornaviridae Infections/virology*
* Respiratory Tract Infections/virology*
* Rhinovirus/classification*
* Rhinovirus/genetics*
* Rhinovirus/isolation & purification
Secondary Source ID:
* GENBANK/GQ415051
* GENBANK/GQ415052
Grant Support:
* HL071609/HL/NHLBI NIH HHS/United States
-
-----