tetano
Editor, Senior Moderator
Arch Environ Occup Health
. 2021 Mar 22;1-13.
doi: 10.1080/19338244.2021.1896986. Online ahead of print.
Ambient hydrogen sulfide exposure increases the severity of influenza A virus infection in swine
Cristina M Santana[SUP] 1 [/SUP], Phillip Gauger[SUP] 1 [/SUP], Amber Vetger[SUP] 1 [/SUP], Drew Magstadt[SUP] 1 [/SUP], Dong-Suk Kim[SUP] 1 [/SUP], Denusha Shrestha[SUP] 2 [/SUP], Chandrashekhar Charavaryamath[SUP] 2 [/SUP], Wilson K Rumbeiha[SUP] 3 [/SUP]
Affiliations
Abstract
Hydrogen sulfide (H[SUB]2[/SUB]S) is common in concentrated pig feed operations from the decomposition of manure. Ambient H[SUB]2[/SUB]S is a respiratory tract irritant and an environmental stressor for caretakers and pigs. Influenza A virus (IAV), a zoonotic pathogen, has caused prior pandemics. The effects of H[SUB]2[/SUB]S or IAV alone on the respiratory system have been investigated, but their interaction has not. We hypothesized that exposure to environmentally-relevant H[SUB]2[/SUB]S concentrations increases the pathogenicity of IAV infection in swine. Thirty-five, three-week old pigs of mixed sex were exposed to breathing air or H[SUB]2[/SUB]S via inhalation 6 hours daily for 12 days. After 7 days, pigs were inoculated with H3N2 IAV (or a placebo). Results showed that ambient H[SUB]2[/SUB]S increased the severity of respiratory distress and lung pathology. H[SUB]2[/SUB]S also suppressed IL-IL-1?, IL-6 and IL-8 cytokine response in BALF and increased viral loads and nasal shedding.
Keywords: Hydrogen sulfide; environmental stressor; influenza A virus; pigs; zoonotic disease.
. 2021 Mar 22;1-13.
doi: 10.1080/19338244.2021.1896986. Online ahead of print.
Ambient hydrogen sulfide exposure increases the severity of influenza A virus infection in swine
Cristina M Santana[SUP] 1 [/SUP], Phillip Gauger[SUP] 1 [/SUP], Amber Vetger[SUP] 1 [/SUP], Drew Magstadt[SUP] 1 [/SUP], Dong-Suk Kim[SUP] 1 [/SUP], Denusha Shrestha[SUP] 2 [/SUP], Chandrashekhar Charavaryamath[SUP] 2 [/SUP], Wilson K Rumbeiha[SUP] 3 [/SUP]
Affiliations
- PMID: 33750267
- DOI: 10.1080/19338244.2021.1896986
Abstract
Hydrogen sulfide (H[SUB]2[/SUB]S) is common in concentrated pig feed operations from the decomposition of manure. Ambient H[SUB]2[/SUB]S is a respiratory tract irritant and an environmental stressor for caretakers and pigs. Influenza A virus (IAV), a zoonotic pathogen, has caused prior pandemics. The effects of H[SUB]2[/SUB]S or IAV alone on the respiratory system have been investigated, but their interaction has not. We hypothesized that exposure to environmentally-relevant H[SUB]2[/SUB]S concentrations increases the pathogenicity of IAV infection in swine. Thirty-five, three-week old pigs of mixed sex were exposed to breathing air or H[SUB]2[/SUB]S via inhalation 6 hours daily for 12 days. After 7 days, pigs were inoculated with H3N2 IAV (or a placebo). Results showed that ambient H[SUB]2[/SUB]S increased the severity of respiratory distress and lung pathology. H[SUB]2[/SUB]S also suppressed IL-IL-1?, IL-6 and IL-8 cytokine response in BALF and increased viral loads and nasal shedding.
Keywords: Hydrogen sulfide; environmental stressor; influenza A virus; pigs; zoonotic disease.