tetano
Editor, Senior Moderator
Arch Cardiovasc Dis
. 2021 May 21;S1875-2136(21)00086-3.
doi: 10.1016/j.acvd.2021.04.002. Online ahead of print.
Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study
Orianne Weizman[SUP] 1 [/SUP], Delphine Mika[SUP] 2 [/SUP], Joffrey Cellier[SUP] 3 [/SUP], Laura Geneste[SUP] 4 [/SUP], Antonin Trimaille[SUP] 5 [/SUP], Thibaut Pommier[SUP] 6 [/SUP], Vassili Panagides[SUP] 7 [/SUP], Wassima Marsou[SUP] 8 [/SUP], Antoine Deney[SUP] 9 [/SUP], Sabir Attou[SUP] 10 [/SUP], Thomas Delmotte[SUP] 11 [/SUP], Sophie Ribeyrolles[SUP] 12 [/SUP], Pascale Chemaly[SUP] 13 [/SUP], Clément Karsenty[SUP] 9 [/SUP], Gauthier Giordano[SUP] 14 [/SUP], Alexandre Gautier[SUP] 13 [/SUP], Corentin Chaumont[SUP] 15 [/SUP], Pierre Guilleminot[SUP] 6 [/SUP], Audrey Sagnard[SUP] 6 [/SUP], Julie Pastier[SUP] 6 [/SUP], Baptiste Duceau[SUP] 16 [/SUP], Willy Sutter[SUP] 16 [/SUP], Charles Fauvel[SUP] 15 [/SUP], Théo Pezel[SUP] 17 [/SUP], Guillaume Bonnet[SUP] 18 [/SUP], Ariel Cohen[SUP] 19 [/SUP], Victor Waldmann[SUP] 20 [/SUP], Critical COVID-19 France Investigators
Affiliations
Abstract
Background: Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population.
Aims: To assess the burden and impact of cardiovascular comorbidities in women with COVID-19.
Methods: All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death.
Results: Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3±18.0 vs. 65.4±16.0 years; P<0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio
: 0.62, 95% confidence interval [CI]: 0.53-0.72). Age (adjusted HR: 1.05 per 5-year increase, 95% CI: 1.01-1.10), body mass index (adjusted HR: 1.06 per 2-unit increase, 95% CI: 1.02-1.10), chronic kidney disease (adjusted HR: 1.57, 95% CI: 1.11-2.22) and heart failure (adjusted HR: 1.52, 95% CI: 1.04-2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR: 2.41, 95% CI: 1.70-3.44) and troponin (adjusted HR: 2.00, 95% CI: 1.39-2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure.
Conclusions: Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases.
Keywords: COVID-19; Facteurs de risque; Femmes; Outcomes; Risk factors; Résultats; SARS-CoV-2; Women.
. 2021 May 21;S1875-2136(21)00086-3.
doi: 10.1016/j.acvd.2021.04.002. Online ahead of print.
Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study
Orianne Weizman[SUP] 1 [/SUP], Delphine Mika[SUP] 2 [/SUP], Joffrey Cellier[SUP] 3 [/SUP], Laura Geneste[SUP] 4 [/SUP], Antonin Trimaille[SUP] 5 [/SUP], Thibaut Pommier[SUP] 6 [/SUP], Vassili Panagides[SUP] 7 [/SUP], Wassima Marsou[SUP] 8 [/SUP], Antoine Deney[SUP] 9 [/SUP], Sabir Attou[SUP] 10 [/SUP], Thomas Delmotte[SUP] 11 [/SUP], Sophie Ribeyrolles[SUP] 12 [/SUP], Pascale Chemaly[SUP] 13 [/SUP], Clément Karsenty[SUP] 9 [/SUP], Gauthier Giordano[SUP] 14 [/SUP], Alexandre Gautier[SUP] 13 [/SUP], Corentin Chaumont[SUP] 15 [/SUP], Pierre Guilleminot[SUP] 6 [/SUP], Audrey Sagnard[SUP] 6 [/SUP], Julie Pastier[SUP] 6 [/SUP], Baptiste Duceau[SUP] 16 [/SUP], Willy Sutter[SUP] 16 [/SUP], Charles Fauvel[SUP] 15 [/SUP], Théo Pezel[SUP] 17 [/SUP], Guillaume Bonnet[SUP] 18 [/SUP], Ariel Cohen[SUP] 19 [/SUP], Victor Waldmann[SUP] 20 [/SUP], Critical COVID-19 France Investigators
Affiliations
- PMID: 34154954
- DOI: 10.1016/j.acvd.2021.04.002
Abstract
Background: Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population.
Aims: To assess the burden and impact of cardiovascular comorbidities in women with COVID-19.
Methods: All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death.
Results: Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3±18.0 vs. 65.4±16.0 years; P<0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio
: 0.62, 95% confidence interval [CI]: 0.53-0.72). Age (adjusted HR: 1.05 per 5-year increase, 95% CI: 1.01-1.10), body mass index (adjusted HR: 1.06 per 2-unit increase, 95% CI: 1.02-1.10), chronic kidney disease (adjusted HR: 1.57, 95% CI: 1.11-2.22) and heart failure (adjusted HR: 1.52, 95% CI: 1.04-2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR: 2.41, 95% CI: 1.70-3.44) and troponin (adjusted HR: 2.00, 95% CI: 1.39-2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure.
Conclusions: Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases.
Keywords: COVID-19; Facteurs de risque; Femmes; Outcomes; Risk factors; Résultats; SARS-CoV-2; Women.