tetano
Editor, Senior Moderator
Arch Biochem Biophys
. 2022 Jan 24;109124.
doi: 10.1016/j.abb.2022.109124. Online ahead of print.
The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
Sk Sarif Hassan[SUP] 1 [/SUP], Pabitra Pal Choudhury[SUP] 2 [/SUP], Guy W Dayhoff 2nd[SUP] 3 [/SUP], Alaa A A Aljabali[SUP] 4 [/SUP], Bruce D Uhal[SUP] 5 [/SUP], Kenneth Lundstrom[SUP] 6 [/SUP], Nima Rezaei[SUP] 7 [/SUP], Damiano Pizzol[SUP] 8 [/SUP], Parise Adadi[SUP] 9 [/SUP], Amos Lal[SUP] 10 [/SUP], Antonio Soares[SUP] 11 [/SUP], Tarek Mohamed Abd El-Aziz[SUP] 12 [/SUP], Adam M Brufsky[SUP] 13 [/SUP], Gajendra Kumar Azad[SUP] 14 [/SUP], Samendra P Sherchan[SUP] 15 [/SUP], Wagner Baetas-da-Cruz[SUP] 16 [/SUP], Kazuo Takayama[SUP] 17 [/SUP], Ãngel Serrano-Aroca[SUP] 18 [/SUP], Gaurav Chauhan[SUP] 19 [/SUP], Giorgio Palu[SUP] 20 [/SUP], Yogendra Kumar Mishra[SUP] 21 [/SUP], Debmalya Barh[SUP] 22 [/SUP], Raner Jośe Santana Silva[SUP] 23 [/SUP], Bruno Silva Andrade[SUP] 24 [/SUP], Vasco Azevedo[SUP] 25 [/SUP], Aristóteles Góes-Neto[SUP] 26 [/SUP], Nicolas G Bazan[SUP] 27 [/SUP], Elrashdy M Redwan[SUP] 28 [/SUP], Murtaza Tambuwala[SUP] 29 [/SUP], Vladimir N Uversky[SUP] 30 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.
Keywords: ORF10; ORF3a; ORF6; ORF7a; ORF7b; ORF8; Pathogenicity; SARS-CoV-2.
. 2022 Jan 24;109124.
doi: 10.1016/j.abb.2022.109124. Online ahead of print.
The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
Sk Sarif Hassan[SUP] 1 [/SUP], Pabitra Pal Choudhury[SUP] 2 [/SUP], Guy W Dayhoff 2nd[SUP] 3 [/SUP], Alaa A A Aljabali[SUP] 4 [/SUP], Bruce D Uhal[SUP] 5 [/SUP], Kenneth Lundstrom[SUP] 6 [/SUP], Nima Rezaei[SUP] 7 [/SUP], Damiano Pizzol[SUP] 8 [/SUP], Parise Adadi[SUP] 9 [/SUP], Amos Lal[SUP] 10 [/SUP], Antonio Soares[SUP] 11 [/SUP], Tarek Mohamed Abd El-Aziz[SUP] 12 [/SUP], Adam M Brufsky[SUP] 13 [/SUP], Gajendra Kumar Azad[SUP] 14 [/SUP], Samendra P Sherchan[SUP] 15 [/SUP], Wagner Baetas-da-Cruz[SUP] 16 [/SUP], Kazuo Takayama[SUP] 17 [/SUP], Ãngel Serrano-Aroca[SUP] 18 [/SUP], Gaurav Chauhan[SUP] 19 [/SUP], Giorgio Palu[SUP] 20 [/SUP], Yogendra Kumar Mishra[SUP] 21 [/SUP], Debmalya Barh[SUP] 22 [/SUP], Raner Jośe Santana Silva[SUP] 23 [/SUP], Bruno Silva Andrade[SUP] 24 [/SUP], Vasco Azevedo[SUP] 25 [/SUP], Aristóteles Góes-Neto[SUP] 26 [/SUP], Nicolas G Bazan[SUP] 27 [/SUP], Elrashdy M Redwan[SUP] 28 [/SUP], Murtaza Tambuwala[SUP] 29 [/SUP], Vladimir N Uversky[SUP] 30 [/SUP]
Affiliations
- PMID: 35085577
- DOI: 10.1016/j.abb.2022.109124
Abstract
The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.
Keywords: ORF10; ORF3a; ORF6; ORF7a; ORF7b; ORF8; Pathogenicity; SARS-CoV-2.
