tetano
Editor, Senior Moderator
Arch Argent Pediatr
. 2021 Feb;119(1):e26-e35.
doi: 10.5546/aap.2021.eng.e26.
Multisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients
[Article in Spanish, En]
Pedro Taffarel[SUP] 1 [/SUP], Facundo Jorro Bar?n[SUP] 1 [/SUP], Ana Paula Rodr?guez[SUP] 1 [/SUP], Jesica Widmer[SUP] 1 [/SUP], Claudia Meregallia[SUP] 1 [/SUP]
Affiliations
Abstract
in English, Spanish
Multisystem inflammatory syndrome in children related to COVID-19 is defined as the presence of persistent fever, inflammation, and organ dysfunction, with evidence of past or recent severe acute respiratory syndrome coronavirus 2 infection, and excluding other microbial causes. It overlaps with other inflammatory diseases (Kawasaki disease and toxic shock syndrome) and shares some features with hypercytokinemia conditions (hemophagocytic lymphohistiocytosis and macrophage activation syndrome). It differs from these and severe acute COVID-19 in its clinical presentation and laboratory parameters. It has a potentially severe course and may occur with cardiovascular failure; mortality is low (2 %). Here we provide an update on this syndrome and describe the presentation of two clinical cases with cardiovascular dysfunction who required vasoactive support and invasive ventilation. Serum lab tests showed inflammation parameters. Both patients were treated with intravenous immunoglobulin and systemic corticosteroids and had a favorable course.
Keywords: COVID-19; Kawasaki disease; MIS-C; SARS-CoV-2; multisystem inflammatory syndrome in children; multisystem inflammatory syndrome in children temporally associated with SARS-CoV-2.
. 2021 Feb;119(1):e26-e35.
doi: 10.5546/aap.2021.eng.e26.
Multisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients
[Article in Spanish, En]
Pedro Taffarel[SUP] 1 [/SUP], Facundo Jorro Bar?n[SUP] 1 [/SUP], Ana Paula Rodr?guez[SUP] 1 [/SUP], Jesica Widmer[SUP] 1 [/SUP], Claudia Meregallia[SUP] 1 [/SUP]
Affiliations
- PMID: 33458987
- DOI: 10.5546/aap.2021.eng.e26
Abstract
in English, Spanish
Multisystem inflammatory syndrome in children related to COVID-19 is defined as the presence of persistent fever, inflammation, and organ dysfunction, with evidence of past or recent severe acute respiratory syndrome coronavirus 2 infection, and excluding other microbial causes. It overlaps with other inflammatory diseases (Kawasaki disease and toxic shock syndrome) and shares some features with hypercytokinemia conditions (hemophagocytic lymphohistiocytosis and macrophage activation syndrome). It differs from these and severe acute COVID-19 in its clinical presentation and laboratory parameters. It has a potentially severe course and may occur with cardiovascular failure; mortality is low (2 %). Here we provide an update on this syndrome and describe the presentation of two clinical cases with cardiovascular dysfunction who required vasoactive support and invasive ventilation. Serum lab tests showed inflammation parameters. Both patients were treated with intravenous immunoglobulin and systemic corticosteroids and had a favorable course.
Keywords: COVID-19; Kawasaki disease; MIS-C; SARS-CoV-2; multisystem inflammatory syndrome in children; multisystem inflammatory syndrome in children temporally associated with SARS-CoV-2.