tetano
Editor, Senior Moderator
Curr Opin Pharmacol. 2016 Aug 25;30:106-115. doi: 10.1016/j.coph.2016.08.003. [Epub ahead of print]
[h=1]Antiviral therapies on the horizon for influenza.[/h] Naesens L[SUP]1[/SUP], Stevaert A[SUP]2[/SUP], Vanderlinden E[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Adequate response to severe influenza infections or pandemic outbreaks requires two complementary strategies: preventive vaccination and antiviral therapy. The existing influenza drugs, M2 blockers and neuraminidase inhibitors, show modest clinical efficacy and established or potential resistance. In the past three years, several new agents have entered the clinical pipeline and already yielded some promising data from Phase 2 trials. For two main categories, that is, the broadly neutralizing anti-hemagglutinin antibodies and small-molecule inhibitors of the viral polymerase complex, crystallography was instrumental to guide drug development. These structural insights also aid to expand the activity spectrum towards influenza A plus B viruses, or conceive nucleoprotein or polymerase assembly inhibitors. The practice of influenza therapy should radically change in the next decade.
Copyright ? 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PMID: 27570127 DOI: 10.1016/j.coph.2016.08.003
[PubMed - as supplied by publisher] Free full text
[h=1]Antiviral therapies on the horizon for influenza.[/h] Naesens L[SUP]1[/SUP], Stevaert A[SUP]2[/SUP], Vanderlinden E[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Adequate response to severe influenza infections or pandemic outbreaks requires two complementary strategies: preventive vaccination and antiviral therapy. The existing influenza drugs, M2 blockers and neuraminidase inhibitors, show modest clinical efficacy and established or potential resistance. In the past three years, several new agents have entered the clinical pipeline and already yielded some promising data from Phase 2 trials. For two main categories, that is, the broadly neutralizing anti-hemagglutinin antibodies and small-molecule inhibitors of the viral polymerase complex, crystallography was instrumental to guide drug development. These structural insights also aid to expand the activity spectrum towards influenza A plus B viruses, or conceive nucleoprotein or polymerase assembly inhibitors. The practice of influenza therapy should radically change in the next decade.
Copyright ? 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PMID: 27570127 DOI: 10.1016/j.coph.2016.08.003
[PubMed - as supplied by publisher] Free full text