tetano
Editor, Senior Moderator
Clin Lab Med. 2014 Jun;34(2):387-408. doi: 10.1016/j.cll.2014.02.010. Epub 2014 Apr 12.
Antiviral Resistance in Influenza Viruses: Laboratory Testing.
Laplante J1, St George K2.
Author information
Abstract
Influenza continues to be a significant health care issue. Although vaccination is the major line of defense, antiviral drugs play an important role in prophylaxis and disease management. Approved drugs for influenza are currently limited to those that target the viral matrix protein or neuraminidase enzyme. Resistance-associated sequence changes in the genes encoding these proteins have been extensively studied. Available methods for genotypic and phenotypic antiviral susceptibility testing have expanded and are being further developed and improved. The sporadic emergence of drug-resistant variants and the global spread of resistant strains have demonstrated the ongoing need for vigilant testing and surveillance.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Inhibition assays, Matrix gene, Neuraminidase, Pyrosequencing
PMID:
24856534
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24856534
Antiviral Resistance in Influenza Viruses: Laboratory Testing.
Laplante J1, St George K2.
Author information
Abstract
Influenza continues to be a significant health care issue. Although vaccination is the major line of defense, antiviral drugs play an important role in prophylaxis and disease management. Approved drugs for influenza are currently limited to those that target the viral matrix protein or neuraminidase enzyme. Resistance-associated sequence changes in the genes encoding these proteins have been extensively studied. Available methods for genotypic and phenotypic antiviral susceptibility testing have expanded and are being further developed and improved. The sporadic emergence of drug-resistant variants and the global spread of resistant strains have demonstrated the ongoing need for vigilant testing and surveillance.
Copyright ? 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Inhibition assays, Matrix gene, Neuraminidase, Pyrosequencing
PMID:
24856534
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24856534