Giuseppe
Emeritus
Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus. (Antiviral Res., abstract, RA-1011, edited)
Antiviral Res. 2010 Jan 7. [Epub ahead of print]
Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus.
Zhiqiang W, Yaowu Y, Fan Y, Jian Y, Yongfeng H, Lina Z, Jianwei W, Qi J. - State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100176, PR China.
In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A549 cells. Ten small interfering RNAs (siRNAs) targeting extremely conserved regions among multiple NIAV genomes could effectively block the replication of NIAV strain A/Beijing/01/2009 (H1N1) in A549 cells. This study may be useful to confront the sudden emergence of NIAV infection.
Copyright ? 2010. Published by Elsevier B.V.
PMID: 20060420 [PubMed - as supplied by publisher]
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Antiviral Res. 2010 Jan 7. [Epub ahead of print]
Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus.
Zhiqiang W, Yaowu Y, Fan Y, Jian Y, Yongfeng H, Lina Z, Jianwei W, Qi J. - State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100176, PR China.
In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A549 cells. Ten small interfering RNAs (siRNAs) targeting extremely conserved regions among multiple NIAV genomes could effectively block the replication of NIAV strain A/Beijing/01/2009 (H1N1) in A549 cells. This study may be useful to confront the sudden emergence of NIAV infection.
Copyright ? 2010. Published by Elsevier B.V.
PMID: 20060420 [PubMed - as supplied by publisher]
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