tetano
Editor, Senior Moderator
Antiviral Res
. 2024 Nov 20:106040.
doi: 10.1016/j.antiviral.2024.106040. Online ahead of print. Edible bird's nest: N- and O-glycan analysis and synergistic anti-avian influenza virus activity with neuraminidase inhibitors
Nongluk Sriwilaijaroen[SUP] 1 [/SUP], Hisatoshi Hanamatsu[SUP] 2 [/SUP], Ikuko Yokota[SUP] 2 [/SUP], Takashi Nishikaze[SUP] 3 [/SUP], Tetsuo Ijichi[SUP] 4 [/SUP], Tadanobu Takahashi[SUP] 5 [/SUP], Yoshihiro Sakoda[SUP] 6 [/SUP], Jun-Ichi Furukawa[SUP] 7 [/SUP], Yasuo Suzuki[SUP] 5 [/SUP]
Affiliations
Zoonotic avian influenza viruses have continued to infect people on occasion. During treatment, antiviral resistant viruses have occasionally emerged, highlighting the need for a novel strategy for treating human illness. Edible bird's nest (EBN), swiftlet saliva consumed for health purposes, possesses anti-avian viral activity by inhibiting receptor-binding hemagglutinin (HA) activity. Glycan analysis revealed an abundance of α2,3Neu5Ac decoy receptors in EBN. Fucosylated tri-α2,3Neu5Ac tri-antennary N-glycans (N-35) and di-α2,3Neu5Ac core 2 O-glycans (O-15) are predominant, accounting for 53.46% and 44.66% of total N- and O-glycan amounts, respectively. Isobologram analysis revealed that EBN had a strong synergistic effect with either oseltamivir carboxylate or zanamivir, a competitive inhibitor of receptor-destroying neuraminidases (NAs), against the avian H5N1 virus. Taken together, EBN has the potential to be developed as a food-derived avian viral trap to prevent and decrease avian virus infection as well as in combination with a viral releasing-NA inhibitor to increase therapeutic potency, reduce toxicity, delay resistance development, and potentially prevent pandemic onset.
Keywords: Avian influenza virus; Drug combination; Edible bird’s nest; Glycans; Hemagglutinin inhibitor; Neuraminidase inhibitor.
. 2024 Nov 20:106040.
doi: 10.1016/j.antiviral.2024.106040. Online ahead of print. Edible bird's nest: N- and O-glycan analysis and synergistic anti-avian influenza virus activity with neuraminidase inhibitors
Nongluk Sriwilaijaroen[SUP] 1 [/SUP], Hisatoshi Hanamatsu[SUP] 2 [/SUP], Ikuko Yokota[SUP] 2 [/SUP], Takashi Nishikaze[SUP] 3 [/SUP], Tetsuo Ijichi[SUP] 4 [/SUP], Tadanobu Takahashi[SUP] 5 [/SUP], Yoshihiro Sakoda[SUP] 6 [/SUP], Jun-Ichi Furukawa[SUP] 7 [/SUP], Yasuo Suzuki[SUP] 5 [/SUP]
Affiliations
- PMID: 39577572
- DOI: 10.1016/j.antiviral.2024.106040
Zoonotic avian influenza viruses have continued to infect people on occasion. During treatment, antiviral resistant viruses have occasionally emerged, highlighting the need for a novel strategy for treating human illness. Edible bird's nest (EBN), swiftlet saliva consumed for health purposes, possesses anti-avian viral activity by inhibiting receptor-binding hemagglutinin (HA) activity. Glycan analysis revealed an abundance of α2,3Neu5Ac decoy receptors in EBN. Fucosylated tri-α2,3Neu5Ac tri-antennary N-glycans (N-35) and di-α2,3Neu5Ac core 2 O-glycans (O-15) are predominant, accounting for 53.46% and 44.66% of total N- and O-glycan amounts, respectively. Isobologram analysis revealed that EBN had a strong synergistic effect with either oseltamivir carboxylate or zanamivir, a competitive inhibitor of receptor-destroying neuraminidases (NAs), against the avian H5N1 virus. Taken together, EBN has the potential to be developed as a food-derived avian viral trap to prevent and decrease avian virus infection as well as in combination with a viral releasing-NA inhibitor to increase therapeutic potency, reduce toxicity, delay resistance development, and potentially prevent pandemic onset.
Keywords: Avian influenza virus; Drug combination; Edible bird’s nest; Glycans; Hemagglutinin inhibitor; Neuraminidase inhibitor.