tetano
Editor, Senior Moderator
Emerg Infect Dis. 2017 Apr;23(4):686-690. doi: 10.3201/eid2304.161876.
[h=1]Antiviral Drug-Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016.[/h] Baranovich T, Vongphrachanh P, Ketmayoon P, Sisouk T, Chomlasack K, Khanthamaly V, Nguyen HT, Mishin VP, Marjuki H, Barnes JR, Garten RJ, Stevens J, Wentworth DE, Gubareva LV.
[h=3]Abstract[/h] In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
[h=4]KEYWORDS:[/h] H134N substitution; Laos; antimicrobial resistance; antiviral drug?resistant; influenza; influenza B viruses; mutation; neuraminidase; viruses
PMID: 28322707 DOI: 10.3201/eid2304.161876
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[h=1]Antiviral Drug-Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016.[/h] Baranovich T, Vongphrachanh P, Ketmayoon P, Sisouk T, Chomlasack K, Khanthamaly V, Nguyen HT, Mishin VP, Marjuki H, Barnes JR, Garten RJ, Stevens J, Wentworth DE, Gubareva LV.
[h=3]Abstract[/h] In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
[h=4]KEYWORDS:[/h] H134N substitution; Laos; antimicrobial resistance; antiviral drug?resistant; influenza; influenza B viruses; mutation; neuraminidase; viruses
PMID: 28322707 DOI: 10.3201/eid2304.161876
Free full text