tetano
Editor, Senior Moderator
Adv Virol. 2011;2011:572868. Epub 2011 Nov 28.
Antiviral and virucidal activities of nα-cocoyl-L-arginine ethyl ester.
Yamasaki H, Tsujimoto K, Ikeda K, Suzuki Y, Arakawa T, Koyama AH.
Source
Division of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, Japan.
Abstract
Various amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenza A virus (IAV), and poliovirus type 1 (PV-1) in comparison to benzalkonium chloride (BKC) and sodium dodecylsulfate (SDS) as a cationic and anionic control detergent and also to other commercially available disinfectants. While these amino acid-derived compounds were all effective against HSV-1 and HSV-2, CAE and Amilite were the most effective. These two compounds were, however, not as effective against IAV, another enveloped virus, as against HSV. Cytotoxicity of CAE was weak; at 0.012%, only 5% of the cells were killed under the conditions, in which 100% cells were killed by either SDS or BKC. In addition to these direct virucidal effects, CAE inhibited the virus growth in the HSV-1- or PV-1-infected cells even at 0.01%. These results suggest a potential application of CAE as a therapeutic or preventive medicine against HSV superficial infection at body surface.
PMID:
22312346
[PubMed - in process]
PMCID: PMC3265308
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/22312346
Antiviral and virucidal activities of nα-cocoyl-L-arginine ethyl ester.
Yamasaki H, Tsujimoto K, Ikeda K, Suzuki Y, Arakawa T, Koyama AH.
Source
Division of Virology, Department of Cellular and Molecular Medicine, Graduate School of Medicine, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, Japan.
Abstract
Various amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenza A virus (IAV), and poliovirus type 1 (PV-1) in comparison to benzalkonium chloride (BKC) and sodium dodecylsulfate (SDS) as a cationic and anionic control detergent and also to other commercially available disinfectants. While these amino acid-derived compounds were all effective against HSV-1 and HSV-2, CAE and Amilite were the most effective. These two compounds were, however, not as effective against IAV, another enveloped virus, as against HSV. Cytotoxicity of CAE was weak; at 0.012%, only 5% of the cells were killed under the conditions, in which 100% cells were killed by either SDS or BKC. In addition to these direct virucidal effects, CAE inhibited the virus growth in the HSV-1- or PV-1-infected cells even at 0.01%. These results suggest a potential application of CAE as a therapeutic or preventive medicine against HSV superficial infection at body surface.
PMID:
22312346
[PubMed - in process]
PMCID: PMC3265308
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/22312346