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Antiviral activity of crude extracts of Eugenia jambolana Lam. against highly pathogenic avian influenza (H5N1) virus

tetano

tetano

Editor, Senior Moderator
Indian J Exp Biol. 2012 Mar;50(3):179-86.
Antiviral activity of crude extracts of Eugenia jambolana Lam. against highly pathogenic avian influenza (H5N1) virus.
Sood R, Swarup D, Bhatia S, Kulkarni DD, Dey S, Saini M, Dubey SC.
Source

High Security Animal Disease Laboratory, Indian Veterinary Research Institute, Anand Nagar, Bhopal, Madhya Pradesh 462021, India. richa_bhatia@yahoo.com
Abstract

Crude extracts of leaves and bark of E. jambolana were tested for antiviral activity against highly pathogenic avian influenza virus (H5N1) by CPE reduction assay in three different layouts to elucidate virucidal, post-exposure and preexposure antiviral activity of the extracts. The cold and hot aqueous extracts of bark and hot aqueous extract of leaves of E. jambolana showed significant virucidal activity (100% inhibition) which was further confirmed in virus yield reduction assay (-98 to 99% reduction) and by egg based in ovo assay. The selective index (CC50/EC50) of hot aqueous extract (248) and cold aqueous extract (43.5) of bark of E. jambolana showed their antiviral potential against H5N1 virus. The significant virucidal activity of leaves and bark of E. jambolana merits further investigation as it may provide alternative antiviral agent for managing avian influenza infections in poultry farms and potential avian-human transmission.

PMID:
22439432
[PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/22439432
 
Re: Antiviral activity of crude extracts of Eugenia jambolana Lam. against highly pathogenic avian influenza (H5N1) virus

Native Indian tree to fight bird flu
Crude extract of the leaf and bark of native tree Eugenia jambolona has been reported to destroy the deadly avian influenza virus H5N11. The plant-derived extract can be used as an alternative to chemically synthesised antivirals.

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http://www.nature.com/nindia/2012/120326/full/nindia.2012.42.html
 
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