tetano
Editor, Senior Moderator
Antimicrob Agents Chemother
. 2021 Mar 29;AAC.02718-20.
doi: 10.1128/AAC.02718-20. Online ahead of print.
Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain
Beatriz Mengual-Chuli?[SUP] 1 [/SUP], Andr?s Alonso-Cordero[SUP] 1 [/SUP], Laura Cano[SUP] 1 [/SUP], M Del Mar Mosquera[SUP] 2 [/SUP], Patricia de Molina[SUP] 2 [/SUP], Roser Vendrell[SUP] 2 [/SUP], Mariana Reyes-Prieto[SUP] 3 [/SUP], Mireia Jan?[SUP] 4 [/SUP], Nuria Torner[SUP] 4 [/SUP], Ana Isabel Mart?nez[SUP] 4 [/SUP], Jordi Vila[SUP] 2 [/SUP], Javier D?ez-Domingo[SUP] 5 [/SUP], M ?ngeles Marcos[SUP] 2 [/SUP], F Xavier L?pez-Labrador, Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI)
Affiliations
Abstract
Molecular surveillance by whole genome sequencing was used to monitor the susceptibility of circulating Influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analysed, but none associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.
. 2021 Mar 29;AAC.02718-20.
doi: 10.1128/AAC.02718-20. Online ahead of print.
Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain
Beatriz Mengual-Chuli?[SUP] 1 [/SUP], Andr?s Alonso-Cordero[SUP] 1 [/SUP], Laura Cano[SUP] 1 [/SUP], M Del Mar Mosquera[SUP] 2 [/SUP], Patricia de Molina[SUP] 2 [/SUP], Roser Vendrell[SUP] 2 [/SUP], Mariana Reyes-Prieto[SUP] 3 [/SUP], Mireia Jan?[SUP] 4 [/SUP], Nuria Torner[SUP] 4 [/SUP], Ana Isabel Mart?nez[SUP] 4 [/SUP], Jordi Vila[SUP] 2 [/SUP], Javier D?ez-Domingo[SUP] 5 [/SUP], M ?ngeles Marcos[SUP] 2 [/SUP], F Xavier L?pez-Labrador, Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI)
Affiliations
- PMID: 33782005
- DOI: 10.1128/AAC.02718-20
Abstract
Molecular surveillance by whole genome sequencing was used to monitor the susceptibility of circulating Influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analysed, but none associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.