Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
Dae Hun Kim a, Ji-Young Choi a, Hae Won Kim a, So Hyun Kim b, Doo Ryeon Chung c, Kyong Ran Peck c, Visanu Thamlikitkul d, Thomas Man-kit So e, Rohani M. D. Yasin f, Po-Ren Hsueh g, Celia C. Carlos h, Li Yang Hsu i, Latre Buntaran j, M. K. Lalitha k, Jae-Hoon Song b,c and Kwan Soo Ko a,b
Author Affiliations: Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea<SUP>a </SUP>Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea<SUP>b </SUP>Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea<SUP>c </SUP>Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand<SUP>d </SUP>Department of Medicine, Princess Margaret Hospital, Hong Kong<SUP>e </SUP>Bacteriology Unit, Specialized Diagnostic Centre, Institute for Medical Research, Kuala Lumpur, Malaysia<SUP>f </SUP>Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan<SUP>g </SUP>Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine, Manila, Philippines<SUP>h </SUP>Department of Medicine, National University Hospital, Singapore<SUP>i </SUP>Children's and Maternity, Harapan Kita Hospital, Jakarta, Indonesia<SUP>j </SUP>Department of Microbiology, Madras Medical Mission, Chennai, India<SUP>k</SUP>
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ABSTRACT
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone (GC) 2, was the most prevalent in most Asian locales (83/108 isolates, 76.9%). CC108 or GC1 was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. bla<SUB>OXA-24</SUB> was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant with diverse variants. The significance of this study is to identify the spread of global clones of carbapenem-resistant A. baumannii in Asia.
FOOTNOTES
Corresponding author: Kwan Soo Ko, PhD, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon 440-746, Korea, Phone: 82-31-299-6223, Fax: 82-31-299-6229, E-mail: ksko@skku.edu
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
Dae Hun Kim a, Ji-Young Choi a, Hae Won Kim a, So Hyun Kim b, Doo Ryeon Chung c, Kyong Ran Peck c, Visanu Thamlikitkul d, Thomas Man-kit So e, Rohani M. D. Yasin f, Po-Ren Hsueh g, Celia C. Carlos h, Li Yang Hsu i, Latre Buntaran j, M. K. Lalitha k, Jae-Hoon Song b,c and Kwan Soo Ko a,b
Author Affiliations: Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea<SUP>a </SUP>Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea<SUP>b </SUP>Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea<SUP>c </SUP>Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand<SUP>d </SUP>Department of Medicine, Princess Margaret Hospital, Hong Kong<SUP>e </SUP>Bacteriology Unit, Specialized Diagnostic Centre, Institute for Medical Research, Kuala Lumpur, Malaysia<SUP>f </SUP>Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan<SUP>g </SUP>Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine, Manila, Philippines<SUP>h </SUP>Department of Medicine, National University Hospital, Singapore<SUP>i </SUP>Children's and Maternity, Harapan Kita Hospital, Jakarta, Indonesia<SUP>j </SUP>Department of Microbiology, Madras Medical Mission, Chennai, India<SUP>k</SUP>
<SUP></SUP>
ABSTRACT
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone (GC) 2, was the most prevalent in most Asian locales (83/108 isolates, 76.9%). CC108 or GC1 was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. bla<SUB>OXA-24</SUB> was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant with diverse variants. The significance of this study is to identify the spread of global clones of carbapenem-resistant A. baumannii in Asia.
FOOTNOTES
Corresponding author: Kwan Soo Ko, PhD, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon 440-746, Korea, Phone: 82-31-299-6223, Fax: 82-31-299-6229, E-mail: ksko@skku.edu
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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