Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria
Laurent Poirel 1,2, Encho Savov 3, Arzu Nazli 1, Angelina Trifonova 3, Iva Todorova 3, Ivanka Gergova 3 and Patrice Nordmann 1,2*
Author Affiliations: <SUP>1</SUP>Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland <SUP>2</SUP>INSERM U914, South-Paris Medical School, K.-Bic?tre, France <SUP>3</SUP>Laboratory of Microbiology, Military Medical Academy, Sofia, Bulgaria
Published ahead of print 10 February 2014, doi: 10.1128/AAC.02571-13 <CITE>AAC.02571-13 </CITE>
<CITE></CITE>
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<CITE></CITE>ABSTRACT
Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum ?-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB conferring high-level resistance to all aminoglycosides. All those isolates were clonally-related and belonged to the same sequence type ST101. In addition to firstly identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.
FOOTNOTES
*Corresponding author. Mailing address: Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, rue Albert-Gockel 3, CH-1700 Fribourg, Switzerland. Phone: 41-26-300-9581. E-mail: patrice.nordmann@unifr.ch
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
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Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria
Laurent Poirel 1,2, Encho Savov 3, Arzu Nazli 1, Angelina Trifonova 3, Iva Todorova 3, Ivanka Gergova 3 and Patrice Nordmann 1,2*
Author Affiliations: <SUP>1</SUP>Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland <SUP>2</SUP>INSERM U914, South-Paris Medical School, K.-Bic?tre, France <SUP>3</SUP>Laboratory of Microbiology, Military Medical Academy, Sofia, Bulgaria
Published ahead of print 10 February 2014, doi: 10.1128/AAC.02571-13 <CITE>AAC.02571-13 </CITE>
<CITE></CITE>
<CITE></CITE>
<CITE></CITE>ABSTRACT
Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum ?-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB conferring high-level resistance to all aminoglycosides. All those isolates were clonally-related and belonged to the same sequence type ST101. In addition to firstly identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.
FOOTNOTES
*Corresponding author. Mailing address: Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, rue Albert-Gockel 3, CH-1700 Fribourg, Switzerland. Phone: 41-26-300-9581. E-mail: patrice.nordmann@unifr.ch
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
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