tetano
Editor, Senior Moderator
Antimicrob Agents Chemother
. 2024 Apr 8:e0172723.
doi: 10.1128/aac.01727-23. Online ahead of print. Influenza C virus susceptibility to antivirals with different mechanisms of action
Anton Chesnokov[SUP] 1 [/SUP], Andrei A Ivashchenko[SUP] 2 [/SUP], Yoko Matsuzaki[SUP] 3 [/SUP], Emi Takashita[SUP] 4 [/SUP], Vasiliy P Mishin[SUP] 1 [/SUP], Alexandre V Ivachtchenko[SUP] 2 5 [/SUP], Larisa V Gubareva[SUP] 1 [/SUP]
Affiliations
Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC[SUB]50[/SUB] 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.
Keywords: baloxavir; cap-dependent endonuclease inhibitors; drug susceptibility; lectin; polymerase.
. 2024 Apr 8:e0172723.
doi: 10.1128/aac.01727-23. Online ahead of print. Influenza C virus susceptibility to antivirals with different mechanisms of action
Anton Chesnokov[SUP] 1 [/SUP], Andrei A Ivashchenko[SUP] 2 [/SUP], Yoko Matsuzaki[SUP] 3 [/SUP], Emi Takashita[SUP] 4 [/SUP], Vasiliy P Mishin[SUP] 1 [/SUP], Alexandre V Ivachtchenko[SUP] 2 5 [/SUP], Larisa V Gubareva[SUP] 1 [/SUP]
Affiliations
- PMID: 38587392
- DOI: 10.1128/aac.01727-23
Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC[SUB]50[/SUB] 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.
Keywords: baloxavir; cap-dependent endonuclease inhibitors; drug susceptibility; lectin; polymerase.