Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses
Giulia Muratore<SUP>a</SUP>, Beatrice Mercorelli<SUP>a</SUP>, Laura Goracci<SUP>b</SUP>, Gabriele Cruciani<SUP>b</SUP>, Paul Digard<SUP>c</SUP>, Giorgio Pal?<SUP>a</SUP> and Arianna Loregian<SUP>a</SUP>
<SUP></SUP>
Author Affiliations: <SUP>a</SUP>Department of Molecular Medicine, University of Padua, Padua, Italy <SUP>b</SUP>Department of Chemistry, University of Perugia, Perugia, Italy <SUP>c</SUP>Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, United Kingdom
ABSTRACT
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
FOOTNOTES
Received 18 June 2012. Returned for modification 9 July 2012. Accepted 13 August 2012.
Address correspondence to Arianna Loregian, arianna.loregian@unipd.it, or Giorgio Pal?, giorgio.palu@unipd.it.
G.M. and B.M. contributed equally to this work.
Published ahead of print 20 August 2012
Copyright ? 2012, American Society for Microbiology. All Rights Reserved.
-<SUP></SUP>
Author Affiliations: <SUP>a</SUP>Department of Molecular Medicine, University of Padua, Padua, Italy <SUP>b</SUP>Department of Chemistry, University of Perugia, Perugia, Italy <SUP>c</SUP>Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, United Kingdom
ABSTRACT
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
FOOTNOTES
Received 18 June 2012. Returned for modification 9 July 2012. Accepted 13 August 2012.
Address correspondence to Arianna Loregian, arianna.loregian@unipd.it, or Giorgio Pal?, giorgio.palu@unipd.it.
G.M. and B.M. contributed equally to this work.
Published ahead of print 20 August 2012
Copyright ? 2012, American Society for Microbiology. All Rights Reserved.
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