Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Extended-Spectrum CTX-M-15-Producing Klebsiella pneumoniae ST274 in Companion Animals
Laurent Poirel 1, Patrice Nordmann 1,*, S?bastien Ducroz 1, Henri-Jean Boulouis 2, Pascal Arn? 3 and Yves Millemann 4
Author Affiliations: <SUP>1</SUP>Service de Bact?riologie-Virologie, INSERM U914 ?Emerging Resistance to Antibiotics?, H?pital de Bic?tre, Assistance Publique-H?pitaux de Paris, Facult? de M?decine et Universit? Paris-Sud, K.-Bic?tre <SUP>2</SUP>Laboratoire de Microbiologie <SUP>3</SUP>UMR Bipar, Ecophar <SUP>4</SUP>Unit? Microbiologie Alimentaire, S?curit? et Qualit? des Aliments (MASQ), Ecole Nationale V?t?rinaire d'Alfort, Universit? Paris-Est, Maisons-Alfort, France
ABSTRACT
Screening of extended-spectrum ?-lactamase (ESBL)-producing Gram-negatives in companion animals living in the Paris area in France identified a high rate of CTX-M-15-producing Klebsiella pneumoniae. Those isolates were recovered during the 2010-2011 period from both infections and asymptomatic colonization. Sequence typing revealed that most of these isolates belonged to sequence type ST274. Interestingly, the bla<SUB>CTX-M-15</SUB> gene was located on a specific and novel plasmid scaffold. These findings highlight that companion animals may be reservoirs for CTX-M-15-producing K. pneumoniae evolving separately from the human reservoir of CTX-M-15 producers.
FOOTNOTES
* Corresponding author. Mailling address: Service de Bact?riologie-Virologie, H?pital de Bic?tre, 76 rue du g?n?ral Leclerc, 94275 Le Kremlin-Bic?tre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice@bct.aphp.fr
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
-Laurent Poirel 1, Patrice Nordmann 1,*, S?bastien Ducroz 1, Henri-Jean Boulouis 2, Pascal Arn? 3 and Yves Millemann 4
Author Affiliations: <SUP>1</SUP>Service de Bact?riologie-Virologie, INSERM U914 ?Emerging Resistance to Antibiotics?, H?pital de Bic?tre, Assistance Publique-H?pitaux de Paris, Facult? de M?decine et Universit? Paris-Sud, K.-Bic?tre <SUP>2</SUP>Laboratoire de Microbiologie <SUP>3</SUP>UMR Bipar, Ecophar <SUP>4</SUP>Unit? Microbiologie Alimentaire, S?curit? et Qualit? des Aliments (MASQ), Ecole Nationale V?t?rinaire d'Alfort, Universit? Paris-Est, Maisons-Alfort, France
ABSTRACT
Screening of extended-spectrum ?-lactamase (ESBL)-producing Gram-negatives in companion animals living in the Paris area in France identified a high rate of CTX-M-15-producing Klebsiella pneumoniae. Those isolates were recovered during the 2010-2011 period from both infections and asymptomatic colonization. Sequence typing revealed that most of these isolates belonged to sequence type ST274. Interestingly, the bla<SUB>CTX-M-15</SUB> gene was located on a specific and novel plasmid scaffold. These findings highlight that companion animals may be reservoirs for CTX-M-15-producing K. pneumoniae evolving separately from the human reservoir of CTX-M-15 producers.
FOOTNOTES
* Corresponding author. Mailling address: Service de Bact?riologie-Virologie, H?pital de Bic?tre, 76 rue du g?n?ral Leclerc, 94275 Le Kremlin-Bic?tre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice@bct.aphp.fr
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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