Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
Emergence of tigecycline resistance among multidrug-resistant Klebsiella pneumoniae: A nested case-control study
Masayuki Nigo a, Catalina Salinas Cevallos b, Krystina Woods b, Vicente Maco Flores b, Gweneth Francis b, David Perlman b, Manuel Revuelta b, Donna Mildvan b, Mary Waldron b, Tessa Gomez b, Sanjana Koshy b, Tomasz Jodlowski b, William Riley c and J?rg Ruhe b#
Author Affiliations: Department of Medicine<SUP>a </SUP>Division of Infecious Diseases<SUP>b </SUP>Department of Pathology<SUP>c</SUP>, Beth Israel Medical Center, New York, New York, U.S.A.
ABSTRACT
We performed a nested case-control (ratio 1:4) study on the emergence of tigecycline-resistant (TR) multidrug-resistant Klebsiella pneumoniae (MDRKP) among patients who initially presented with a tigecycline-susceptible MDRKP. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted OR 5.06, 95% CI 1.80 to 14.23; P=0.002) was the only independent predictor of subsequent isolation of a TR strain.
FOOTNOTES
#Corresponding author: J?rg Ruhe, MD MPH, Division of Infectious Diseases, Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, Phone: (212) 420-4005, Fax : (212) 420-4498, Email: jruhe@chpnet.org
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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Emergence of tigecycline resistance among multidrug-resistant Klebsiella pneumoniae: A nested case-control study
Masayuki Nigo a, Catalina Salinas Cevallos b, Krystina Woods b, Vicente Maco Flores b, Gweneth Francis b, David Perlman b, Manuel Revuelta b, Donna Mildvan b, Mary Waldron b, Tessa Gomez b, Sanjana Koshy b, Tomasz Jodlowski b, William Riley c and J?rg Ruhe b#
Author Affiliations: Department of Medicine<SUP>a </SUP>Division of Infecious Diseases<SUP>b </SUP>Department of Pathology<SUP>c</SUP>, Beth Israel Medical Center, New York, New York, U.S.A.
ABSTRACT
We performed a nested case-control (ratio 1:4) study on the emergence of tigecycline-resistant (TR) multidrug-resistant Klebsiella pneumoniae (MDRKP) among patients who initially presented with a tigecycline-susceptible MDRKP. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted OR 5.06, 95% CI 1.80 to 14.23; P=0.002) was the only independent predictor of subsequent isolation of a TR strain.
FOOTNOTES
#Corresponding author: J?rg Ruhe, MD MPH, Division of Infectious Diseases, Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, Phone: (212) 420-4005, Fax : (212) 420-4498, Email: jruhe@chpnet.org
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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