Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full page: (LINK). Abstract, edited.]
DIM-1 metallo-β-lactamase discovered in Pseudomonas stutzeri from 2000; a retrospective molecular analysis
Lalitagauri M. Deshpande 1, Ronald N. Jones 1,2,Leah N. Woosley 1 and Mariana Castanheira 1
Author Affiliations: <SUP>1</SUP>JMI Laboratories, North Liberty, Iowa, USA 52317 <SUP>2</SUP>Tufts University School of Medicine, Boston, Massachusetts, USA 02111
ABSTRACT
Among 220 Gram-negative bacilli clinical isolates collected in India during 2000, twenty-two strains showing elevated imipenem MIC values were evaluated for carbapenemase production. One DIM-1 producing Pseudomonas stutzeri was detected and no other carbapenemase-encoding genes were identified. This detection of a DIM-1-producing P. stutzeri from India predating the finding of this gene in the index Dutch strain and the very recent detection of DIM-1 in Africa suggests an unidentified environmental source of this metallo-β-lactamase gene.
FOOTNOTES
Corresponding Author: Mariana Castanheira, PhD, JMI Laboratories, 345 Beaver Kreek Ctr, Ste A, North Liberty, Iowa, 52317, USA, Phone: 319-665-3370, Fax: 319-665-3371,mariana-castanheira@jmilabs.com
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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DIM-1 metallo-β-lactamase discovered in Pseudomonas stutzeri from 2000; a retrospective molecular analysis
Lalitagauri M. Deshpande 1, Ronald N. Jones 1,2,Leah N. Woosley 1 and Mariana Castanheira 1
Author Affiliations: <SUP>1</SUP>JMI Laboratories, North Liberty, Iowa, USA 52317 <SUP>2</SUP>Tufts University School of Medicine, Boston, Massachusetts, USA 02111
ABSTRACT
Among 220 Gram-negative bacilli clinical isolates collected in India during 2000, twenty-two strains showing elevated imipenem MIC values were evaluated for carbapenemase production. One DIM-1 producing Pseudomonas stutzeri was detected and no other carbapenemase-encoding genes were identified. This detection of a DIM-1-producing P. stutzeri from India predating the finding of this gene in the index Dutch strain and the very recent detection of DIM-1 in Africa suggests an unidentified environmental source of this metallo-β-lactamase gene.
FOOTNOTES
Corresponding Author: Mariana Castanheira, PhD, JMI Laboratories, 345 Beaver Kreek Ctr, Ste A, North Liberty, Iowa, 52317, USA, Phone: 319-665-3370, Fax: 319-665-3371,mariana-castanheira@jmilabs.com
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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